EIF3B and NREP

Number of citations of the paper that reports this interaction (PubMedID 25336651)
72

Data Source:
BioGRID (pull down)

		EIF3B	NREP
Description		eukaryotic translation initiation factor 3 subunit B	neuronal regeneration related protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Cytoplasmic Stress Granule Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation	Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Regulation Of Neuron Differentiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Dimensional psychopathology (Social) ( 29496196)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683) Gut microbiota relative abundance (Sutterella) ( 33208821) Hematocrit ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Platelet count ( 27863252 32888494 33545615) Plateletcrit ( 27863252 32888494) Reaction time ( 29844566) Red blood cell count ( 29403010 32888494) Thyroid cancer ( 28195142)
Interacting Genes		18 interacting genes: BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 GPRASP3 IL2RB LMO2 NDUFAB1 NF2 NREP PAIP1 PBX4 RPS6KB1 TBC1D23 TNNI1 UPF1	5 interacting genes: ATM EEF1A1 EIF3B IGSF21 KMT2B
Entrez ID		8662	9315
HPRD ID		06795	09545
Ensembl ID		ENSG00000106263	ENSG00000134986
Uniprot IDs		P55884	Q16612
PDB IDs		2KRB 2NLW 5K1H 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Cytoplasmic Translational Initiation Translational Initiation Translation Initiation Factor Activity Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translation Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Protein-RNA Complex Assembly XY Body Regulation Of Translational Initiation Cytosol RNA Binding Positive Regulation Of Translation Behavioral Fear Response Behavioral Defense Response Fear Response Regulation Of Translation Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Acyl Carrier Activity
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