EIF3B

Description		eukaryotic translation initiation factor 3 subunit B
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Cytoplasmic Stress Granule Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Molecular Adaptor Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Dimensional psychopathology (Social) ( 29496196)
Interacting Genes		18 interacting genes: BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 GPRASP3 IL2RB LMO2 NDUFAB1 NF2 NREP PAIP1 PBX4 RPS6KB1 TBC1D23 TNNI1 UPF1
Entrez ID		8662
HPRD ID		06795
Ensembl ID		ENSG00000106263
Uniprot IDs		P55884
PDB IDs		2KRB 2NLW 5K1H 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Cytoplasmic Translational Initiation Translational Initiation Translation Initiation Factor Activity Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translation Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Protein-RNA Complex Assembly XY Body Regulation Of Translational Initiation Cytosol RNA Binding Positive Regulation Of Translation Behavioral Fear Response Behavioral Defense Response Fear Response Regulation Of Translation Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Acyl Carrier Activity
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