EIF3A and CACNA1A

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		EIF3A	CACNA1A
Gene Name		eukaryotic translation initiation factor 3, subunit A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Dendrite Cell Projection Neuronal Cell Body
	Molecular Function	Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Poly(A) RNA Binding	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Sulfur Amino Acid Metabolic Process Glucose Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Neuromuscular Synaptic Transmission Synapse Assembly Adult Walking Behavior Cell Death Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Cell Growth Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Transmission Of Nerve Impulse Spinal Cord Motor Neuron Differentiation Cerebellum Maturation Cerebellar Molecular Layer Development Cerebellar Purkinje Cell Differentiation Vestibular Nucleus Development Cellular Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Regulation Of Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Neurotransmitter Metabolic Process Hormone Metabolic Process Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Behavioral Response To Pain Calcium Ion-dependent Exocytosis Of Neurotransmitter Dendrite Morphogenesis Regulation Of Axonogenesis Regulation Of Insulin Secretion Musculoskeletal Movement, Spinal Reflex Action Neuromuscular Process Controlling Balance Membrane Depolarization Rhythmic Synaptic Transmission Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Integration of energy metabolism Regulation of insulin secretion Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs			Pregabalin Verapamil Loperamide Bepridil
Diseases
GWAS
Protein-Protein Interactions		16 interactors: BBS1 BBS4 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FBXO32 REL RNF139 TFIP11 UPF1 YWHAZ	92 interactors: ABCA2 ABI1 ACTN1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 ASNA1 BTG3 BZRAP1 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LPHN1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TUBB2B UQCRC2 VARS VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		8661	773
HPRD ID		03618	03004
Ensembl ID		ENSG00000107581	ENSG00000141837
Uniprot IDs		F5H335 Q14152	B5TYJ1 O00555 Q9NS89
PDB IDs			3BXK
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Formation Of Translation Preinitiation Complex Translation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Gene Expression Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Cellular Component Assembly Ribonucleoprotein Complex Biogenesis Regulation Of Metabolic Process Nonmotile Primary Cilium Assembly Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Photoreceptor Cell Maintenance RNA Catabolic Process Cellular Metabolic Process MRNA Metabolic Process Cellular Response To Hormone Stimulus Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Macromolecular Complex Assembly Cellular Protein Metabolic Process Cerebellar Molecular Layer Development Spliceosomal Complex Disassembly Retina Homeostasis Response To Cytokine MRNA 3'-end Processing Vestibular Nucleus Development Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Metabolic Process Positive Regulation Of Cilium Assembly Cerebellum Maturation Sensory Processing Musculoskeletal Movement, Spinal Reflex Action Regulation Of Cellular Process RNA 3'-end Processing MRNA Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Golgi Reassembly Gamma-aminobutyric Acid Secretion Response To Hormone Cytokine-mediated Signaling Pathway Aromatic Compound Catabolic Process	Secretion By Cell Secretion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Voltage-gated Calcium Channel Activity Detection Of Visible Light Enzyme Linked Receptor Protein Signaling Pathway Detection Of Light Stimulus Multicellular Organismal Development Phototransduction, Visible Light Anatomical Structure Development Cellular Localization Axon Development Developmental Process Establishment Of Localization In Cell Phototransduction Regulation Of Cellular Process System Development Axonogenesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Detection Of Abiotic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Degranulation Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Regulation Of Cation Channel Activity Axon Guidance Nervous System Development Detection Of Calcium Ion Regulation Of Intracellular Cholesterol Transport Regulation Of Cell Communication By Electrical Coupling Neuron Projection Morphogenesis Exocytosis Neuron Projection Development Cellular Response To Growth Factor Stimulus Neuron Differentiation Inositol Phosphate Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Cell Part Morphogenesis Response To Growth Factor Cell Surface Receptor Signaling Pathway Negative Regulation Of Cation Channel Activity Platelet Activation Cell-cell Signaling Nerve Growth Factor Processing Pathogenesis Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		43s coerce compartmentalization compartmentalize compartmentalized concentrating evolve exited factories factory machinery margins nonstructural obstacle orthoreoviruses pic preinitiation ps6r reentered reovirus reoviruses ribopuromycylation sigmans spatiotemporally synthesizing tubulovesicular undertook vf visualize	acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage
Tagcloud (Difference) ?		43s coerce compartmentalization compartmentalize compartmentalized concentrating evolve exited factories factory machinery margins nonstructural obstacle orthoreoviruses pic preinitiation ps6r reentered reovirus reoviruses ribopuromycylation sigmans spatiotemporally synthesizing tubulovesicular undertook vf visualize	acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage
Tagcloud (Intersection) ?