EIF3A and EIF4G2

Number of citations of the paper that reports this interaction (PubMedID 10611228)
41

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		EIF3A	EIF4G2
Description		eukaryotic translation initiation factor 3 subunit A	eukaryotic translation initiation factor 4 gamma 2
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Microtubule Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex Protein-containing Complex Eukaryotic 48S Preinitiation Complex Organelle Multi-eIF Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Receptor Tyrosine Kinase Binding	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Reinitiation Translation Translational Initiation Negative Regulation Of ERK1 And ERK2 Cascade IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation	Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Regulation Of Cell Cycle
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Keratoconus ( 33649486) Plateletcrit ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		26 interacting genes: BBS1 BBS4 BZW2 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FXR1 LAMTOR5 LINC01554 MTNR1B PAIP1 REL RNF10 RNF139 SRPK2 TFIP11 TSC1 UBC UPF1 WEE2-AS1 YWHAZ	18 interacting genes: C1QTNF9 CASP3 CEBPA CREBBP EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 LCOR MKNK1 NCBP1 OGT RNF10 SKIL SUMO2 TTC3
Entrez ID		8661	1982
HPRD ID		03618	09084
Ensembl ID		ENSG00000107581	ENSG00000110321
Uniprot IDs		Q14152	P78344 Q2TU89
PDB IDs		3J8B 3J8C 6YBD 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN	3D3M 3L6A 4IUL 9JJ7
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Regulation Of Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Regulation Of Translational Initiation Eukaryotic 43S Preinitiation Complex Protein-RNA Complex Assembly Post-transcriptional Regulation Of Gene Expression RNA Binding Translation Eukaryotic Translation Initiation Factor 4F Complex RNA Strand Annealing Activity Viral Translational Termination-reinitiation BBSome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cytosol TORC1 Signaling Protein-containing Complex Organization Hippocampus Development Cytoplasm Striatum Development Negative Regulation Of Catabolic Process Regulation Of Cilium Beat Frequency Cerebral Cortex Development Regulation Of Protein Metabolic Process TOR Signaling Retina Homeostasis Protein-containing Complex Assembly Cytoplasmic Stress Granule Regulation Of Circadian Sleep/wake Cycle, Sleep Cellular Component Assembly Ventricular System Development Brain Morphogenesis Translation Factor Activity, RNA Binding Regulation Of TORC1 Signaling Translation Initiation Factor Binding Protein Metabolic Process Negative Regulation Of Autophagy Regulation Of Circadian Sleep/wake Cycle Regulation Of Biological Quality Tube Formation Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Cilium Movement Adult Behavior Regulation Of Macromolecule Biosynthetic Process	Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Translation RNA Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Macromolecule Metabolic Process Macromolecule Biosynthetic Process Protein Metabolic Process Chromatin DNA Binding Regulation Of Gene Expression Regulation Of Translation Regulation Of Translational Initiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Protein-RNA Complex Assembly RNA 7-methylguanosine Cap Binding Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Formation Of Cytoplasmic Translation Initiation Complex RNA Binding MRNA Binding Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Translation Factor Activity, RNA Binding Glutamatergic Synapse Negative Regulation Of Biosynthetic Process Histone Acetyltransferase Complex Response To Glucocorticoid Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Organization Response To Corticosteroid Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Pyroptotic Inflammatory Response DNA-binding Transcription Factor Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Negative Regulation Of RNA-dependent RNA Polymerase Activity Eukaryotic Initiation Factor 4G Binding
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