EIF3A and EIF4G2

Number of citations of the paper that reports this interaction (PMID 9418880)
92

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		EIF3A	EIF4G2
Gene Name		eukaryotic translation initiation factor 3, subunit A	eukaryotic translation initiation factor 4 gamma, 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Poly(A) RNA Binding	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Cell Death Cytokine-mediated Signaling Pathway
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: BBS1 BBS4 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FBXO32 REL RNF139 TFIP11 UPF1 YWHAZ	11 interactors: CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL
Entrez ID		8661	1982
HPRD ID		03618	09084
Ensembl ID		ENSG00000107581	ENSG00000110321
Uniprot IDs		F5H335 Q14152	P78344 Q2TU89
PDB IDs			3D3M 3L6A 4IUL
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Formation Of Translation Preinitiation Complex Translation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Gene Expression Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Cellular Component Assembly Ribonucleoprotein Complex Biogenesis Regulation Of Metabolic Process Nonmotile Primary Cilium Assembly Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Photoreceptor Cell Maintenance RNA Catabolic Process Cellular Metabolic Process MRNA Metabolic Process Cellular Response To Hormone Stimulus Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Macromolecular Complex Assembly Cellular Protein Metabolic Process Cerebellar Molecular Layer Development Spliceosomal Complex Disassembly Retina Homeostasis Response To Cytokine MRNA 3'-end Processing Vestibular Nucleus Development Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Metabolic Process Positive Regulation Of Cilium Assembly Cerebellum Maturation Sensory Processing Musculoskeletal Movement, Spinal Reflex Action Regulation Of Cellular Process RNA 3'-end Processing MRNA Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Golgi Reassembly Gamma-aminobutyric Acid Secretion Response To Hormone Cytokine-mediated Signaling Pathway Aromatic Compound Catabolic Process	Regulation Of Translational Initiation Translational Initiation Regulation Of Translation Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Response To Cytokine Regulation Of Protein Metabolic Process Nuclear Export Gene Expression Biosynthetic Process MRNA Processing Catabolic Process MRNA Metabolic Process Cellular Response To Organic Substance Viral Process Cellular Metabolic Process RNA Processing Nucleocytoplasmic Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Nuclear Transport Response To Organic Substance MRNA Export From Nucleus Lymphocyte Homeostasis Negative Regulation Of RNA-directed RNA Polymerase Activity RNA Export From Nucleus Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Protein Metabolic Process Leukocyte Homeostasis Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Cytokine-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway MRNA Transport Nucleobase-containing Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus
Tagcloud ?		43s coerce compartmentalization compartmentalize compartmentalized concentrating evolve exited factories factory machinery margins nonstructural obstacle orthoreoviruses pic preinitiation ps6r reentered reovirus reoviruses ribopuromycylation sigmans spatiotemporally synthesizing tubulovesicular undertook vf visualize	11p15 4f backcross blot casein codes conserved contains copy exhibits frame germ glycosylation homology interspecific iso northern p82 polypeptide reading segment similarity southern syntenic ubiquitously vertebrates wheat zoo
Tagcloud (Difference) ?		43s coerce compartmentalization compartmentalize compartmentalized concentrating evolve exited factories factory machinery margins nonstructural obstacle orthoreoviruses pic preinitiation ps6r reentered reovirus reoviruses ribopuromycylation sigmans spatiotemporally synthesizing tubulovesicular undertook vf visualize	11p15 4f backcross blot casein codes conserved contains copy exhibits frame germ glycosylation homology interspecific iso northern p82 polypeptide reading segment similarity southern syntenic ubiquitously vertebrates wheat zoo
Tagcloud (Intersection) ?