EIF3A and REL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EIF3A	REL
Gene Name		eukaryotic translation initiation factor 3, subunit A	v-rel avian reticuloendotheliosis viral oncogene homolog
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleoplasm Transcription Factor Complex Cytosol I-kappaB/NF-kappaB Complex
	Molecular Function	Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Poly(A) RNA Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cytokine Production Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Death
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of NF-kappaB in B cells Adaptive Immune System
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Crohn's disease ( 22412388 21102463) Hodgkin's lymphoma ( 21037568) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190) Psoriatic arthritis ( 22170493) Rheumatoid arthritis ( 20453842 19503088) Ulcerative colitis ( 20228799)
Protein-Protein Interactions		16 interactors: BBS1 BBS4 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FBXO32 REL RNF139 TFIP11 UPF1 YWHAZ	201 interactors: A1CF AAAS ACOT8 ACTN3 ADRB2 ADSL AES AGPAT4 ALOX5 AR ARIH2 ARNT2 ASAP3 ATG9A ATPAF2 ATXN1 BARHL2 BID BMF BZRAP1 C11orf68 C12orf75 C1orf109 C20orf195 C9orf72 C9orf91 CABP5 CALM1 CCNE1 CCNJL CDKN2C CEP19 CGGBP1 CHAF1A CHCHD2 CIB3 CINP CKS1B CLIC4 COL20A1 COL8A1 CPNE2 CPSF1 CTNNBIP1 CXCL14 DAAM2 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EGLN3 EIF3A EIF3D EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EML2 EP300 EPHB6 EPM2AIP1 EXOSC1 EXOSC5 EXOSC8 FHIT FHL2 FKBP1B FLAD1 FLNA FOXO4 FUT11 GADD45G GLYCTK GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HSPA4 HSPA8 HSPB7 IL36RN KIAA0100 KLHL32 KLHL40 KRTAP9-4 LASP1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MEMO1 MIEN1 MORF4L1 MRPL10 MTPN MVP NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NOL9 NOTCH1 NR2C2AP NUCB1 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PARK2 PARVG PATE1 PIH1D2 PLCB4 PLEKHN1 POLE2 POLR1A POLR2L POP5 PPP4C PRDM10 PRKAB2 PSMA1 PTGER3 PTK6 R3HDM2 RAB41 RABIF RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RSPH14 SAT1 SDCBP SEC14L4 SEC31A SEPT7 SIN3A SLC39A13 SLC41A3 SLC6A12 SNRNP25 SP1 SRF STK16 STRA13 SZT2 TBP TDO2 TMEM165 TMEM8A TNIP2 TNS2 TRAPPC2L TRIM74 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBE2K UBE2Z VPS25 ZDHHC24 ZNF417 ZNF550 ZNF564 ZNF572 ZNF765
Entrez ID		8661	5966
HPRD ID		03618	01286
Ensembl ID		ENSG00000107581	ENSG00000162924
Uniprot IDs		F5H335 Q14152	Q04864 Q17RU2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Formation Of Translation Preinitiation Complex Translation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Gene Expression Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Cellular Component Assembly Ribonucleoprotein Complex Biogenesis Regulation Of Metabolic Process Nonmotile Primary Cilium Assembly Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Photoreceptor Cell Maintenance RNA Catabolic Process Cellular Metabolic Process MRNA Metabolic Process Cellular Response To Hormone Stimulus Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Macromolecular Complex Assembly Cellular Protein Metabolic Process Cerebellar Molecular Layer Development Spliceosomal Complex Disassembly Retina Homeostasis Response To Cytokine MRNA 3'-end Processing Vestibular Nucleus Development Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Metabolic Process Positive Regulation Of Cilium Assembly Cerebellum Maturation Sensory Processing Musculoskeletal Movement, Spinal Reflex Action Regulation Of Cellular Process RNA 3'-end Processing MRNA Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Golgi Reassembly Gamma-aminobutyric Acid Secretion Response To Hormone Cytokine-mediated Signaling Pathway Aromatic Compound Catabolic Process	Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Cellular Process Regulation Of Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Toll-like Receptor 9 Signaling Pathway Apoptotic Process Cell Death Toll-like Receptor 3 Signaling Pathway Death Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Programmed Cell Death Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of Type I Interferon Production Regulation Of RNA Metabolic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Posttranscriptional Regulation Of Gene Expression Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		43s coerce compartmentalization compartmentalize compartmentalized concentrating evolve exited factories factory machinery margins nonstructural obstacle orthoreoviruses pic preinitiation ps6r reentered reovirus reoviruses ribopuromycylation sigmans spatiotemporally synthesizing tubulovesicular undertook vf visualize	chorionic commercial complementary crude deoxynucleotidyl deoxyuridine digoxigenin exhibiting fractions furthered go gonadotropin haf hcg immunodeficiency inoculation kaposi ks neoplastic nick preceded pregnancy preparations sarcoma slk transferase triphosphate tunel y
Tagcloud (Difference) ?		43s coerce compartmentalization compartmentalize compartmentalized concentrating evolve exited factories factory machinery margins nonstructural obstacle orthoreoviruses pic preinitiation ps6r reentered reovirus reoviruses ribopuromycylation sigmans spatiotemporally synthesizing tubulovesicular undertook vf visualize	chorionic commercial complementary crude deoxynucleotidyl deoxyuridine digoxigenin exhibiting fractions furthered go gonadotropin haf hcg immunodeficiency inoculation kaposi ks neoplastic nick preceded pregnancy preparations sarcoma slk transferase triphosphate tunel y
Tagcloud (Intersection) ?