EIF3A and BZW2

Number of citations of the paper that reports this interaction (PubMedID 21745818)
41

Data Source:
BioGRID (pull down)

		EIF3A	BZW2
Description		eukaryotic translation initiation factor 3 subunit A	basic leucine zipper and W2 domains 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Microtubule Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex Protein-containing Complex Eukaryotic 48S Preinitiation Complex Organelle Multi-eIF Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytoplasm Membrane
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Receptor Tyrosine Kinase Binding	Protein Binding Cadherin Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Reinitiation Translation Translational Initiation Negative Regulation Of ERK1 And ERK2 Cascade IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation	Regulation Of Translation Regulation Of Translational Initiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Keratoconus ( 33649486) Plateletcrit ( 32888494)	Alzheimer's disease (cognitive decline) ( 23535033) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		26 interacting genes: BBS1 BBS4 BZW2 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FXR1 LAMTOR5 LINC01554 MTNR1B PAIP1 REL RNF10 RNF139 SRPK2 TFIP11 TSC1 UBC UPF1 WEE2-AS1 YWHAZ	8 interacting genes: CDC42 CEBPA EIF2A EIF2B1 EIF3A GSK3B LINC01554 OGT
Entrez ID		8661	28969
HPRD ID		03618	16571
Ensembl ID		ENSG00000107581	ENSG00000136261
Uniprot IDs		Q14152	B5MCE7 Q9Y6E2
PDB IDs		3J8B 3J8C 6YBD 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Regulation Of Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Regulation Of Translational Initiation Eukaryotic 43S Preinitiation Complex Protein-RNA Complex Assembly Post-transcriptional Regulation Of Gene Expression RNA Binding Translation Eukaryotic Translation Initiation Factor 4F Complex RNA Strand Annealing Activity Viral Translational Termination-reinitiation BBSome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cytosol TORC1 Signaling Protein-containing Complex Organization Hippocampus Development Cytoplasm Striatum Development Negative Regulation Of Catabolic Process Regulation Of Cilium Beat Frequency Cerebral Cortex Development Regulation Of Protein Metabolic Process TOR Signaling Retina Homeostasis Protein-containing Complex Assembly Cytoplasmic Stress Granule Regulation Of Circadian Sleep/wake Cycle, Sleep Cellular Component Assembly Ventricular System Development Brain Morphogenesis Translation Factor Activity, RNA Binding Regulation Of TORC1 Signaling Translation Initiation Factor Binding Protein Metabolic Process Negative Regulation Of Autophagy Regulation Of Circadian Sleep/wake Cycle Regulation Of Biological Quality Tube Formation Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Cilium Movement Adult Behavior Regulation Of Macromolecule Biosynthetic Process	Translational Initiation Cytoplasmic Translational Initiation Translation Initiation Factor Activity Translation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process ER-nucleus Signaling Pathway Macrophage Differentiation Neuron Projection Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Membraneless Organelle Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glyceryl-ether Monooxygenase Activity Protein-containing Complex GBD Domain Binding Storage Vacuole Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Establishment Of Cell Polarity Endothelin Receptor Signaling Pathway Involved In Heart Process Cellular Response To Cytokine Stimulus Regulation Of Protein-containing Complex Assembly CHOP-C/EBP Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Translation Protein O-acetylglucosaminyltransferase Activity Translation Reinitiation Multi-eIF Complex Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Apolipoprotein A-I Receptor Binding
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