EIF3A and EIF3B

Number of citations of the paper that reports this interaction (PMID 9822659)
19

Data Source:
HPRD (in vitro, in vivo)

		EIF3A	EIF3B
Gene Name		eukaryotic translation initiation factor 3, subunit A	eukaryotic translation initiation factor 3, subunit B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Translation Initiation Factor Activity Structural Molecule Activity Protein Binding Poly(A) RNA Binding	Nucleotide Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Protein Complex Scaffold
	Biological Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: BBS1 BBS4 CACNA1A EIF3B EIF3G EIF3I EIF3J EIF4B EIF4G1 EIF4G2 FBXO32 REL RNF139 TFIP11 UPF1 YWHAZ	8 interactors: BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 IL2RB UPF1
Entrez ID		8661	8662
HPRD ID		03618	06795
Ensembl ID		ENSG00000107581	ENSG00000106263
Uniprot IDs		F5H335 Q14152	P55884
PDB IDs			2KRB 2NLW
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Formation Of Translation Preinitiation Complex Translation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Gene Expression Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Cellular Component Assembly Ribonucleoprotein Complex Biogenesis Regulation Of Metabolic Process Nonmotile Primary Cilium Assembly Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Photoreceptor Cell Maintenance RNA Catabolic Process Cellular Metabolic Process MRNA Metabolic Process Cellular Response To Hormone Stimulus Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Macromolecular Complex Assembly Cellular Protein Metabolic Process Cerebellar Molecular Layer Development Spliceosomal Complex Disassembly Retina Homeostasis Response To Cytokine MRNA 3'-end Processing Vestibular Nucleus Development Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Metabolic Process Positive Regulation Of Cilium Assembly Cerebellum Maturation Sensory Processing Musculoskeletal Movement, Spinal Reflex Action Regulation Of Cellular Process RNA 3'-end Processing MRNA Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Golgi Reassembly Gamma-aminobutyric Acid Secretion Response To Hormone Cytokine-mediated Signaling Pathway Aromatic Compound Catabolic Process	Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Ribonucleoprotein Complex Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Translation Dosage Compensation By Inactivation Of X Chromosome Ribonucleoprotein Complex Biogenesis Dosage Compensation Cytoplasmic Translation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecular Complex Assembly Biosynthetic Process Regulation Of Gene Expression Cellular Component Assembly Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Histone H3-K9 Acetylation Nuclear Export Cellular Protein Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Interleukin-2-mediated Signaling Pathway Response To Cytokine RNA Catabolic Process Formation Of Cytoplasmic Translation Initiation Complex Cellular Response To Indole-3-methanol Regulation Of Metabolic Process Negative Regulation Of Centriole Replication Regulation Of Gene Expression, Epigenetic Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Mature Ribosome Assembly Regulation Of Histone H3-K9 Acetylation Protein Metabolic Process Ribosomal Subunit Export From Nucleus Histone MRNA Catabolic Process Nucleocytoplasmic Transport Cytoplasmic Translational Initiation Nuclear Transport
Tagcloud ?		43s coerce compartmentalization compartmentalize compartmentalized concentrating evolve exited factories factory machinery margins nonstructural obstacle orthoreoviruses pic preinitiation ps6r reentered reovirus reoviruses ribopuromycylation sigmans spatiotemporally synthesizing tubulovesicular undertook vf visualize	attenuation b3 cardiovirulence coxsackievirus cvb3 decisive diagnomx diagnosticpathology eif4b eif4g eu extrapolating ires myocarditis neurovirulence organized p116 p220 p80 playing poliovirus reinforce ribosome sabin sabin3 slide u473 virtual www
Tagcloud (Difference) ?		43s coerce compartmentalization compartmentalize compartmentalized concentrating evolve exited factories factory machinery margins nonstructural obstacle orthoreoviruses pic preinitiation ps6r reentered reovirus reoviruses ribopuromycylation sigmans spatiotemporally synthesizing tubulovesicular undertook vf visualize	attenuation b3 cardiovirulence coxsackievirus cvb3 decisive diagnomx diagnosticpathology eif4b eif4g eu extrapolating ires myocarditis neurovirulence organized p116 p220 p80 playing poliovirus reinforce ribosome sabin sabin3 slide u473 virtual www
Tagcloud (Intersection) ?