TNKS and LNPEP

Number of citations of the paper that reports this interaction (PMID 10988299)
44

Data Source:
HPRD (in vivo, in vitro)

		TNKS	LNPEP
Gene Name		tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	leucyl/cystinyl aminopeptidase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Centromeric Region Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Spindle Pole Nuclear Pore Golgi Apparatus Cytosol Nuclear Membrane	Extracellular Region Intracellular Lysosomal Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Early Endosome Lumen Perinuclear Region Of Cytoplasm
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding	Aminopeptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Mitotic Nuclear Division Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Transport Spindle Assembly Cell Division Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Cell-cell Signaling Female Pregnancy Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I SMAD Protein Signal Transduction Membrane Organization
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer	Antigen processing: Ubiquitination & Proteasome degradation Translocation of GLUT4 to the plasma membrane Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		14 interactors: DISC1 FANCD2 FNBP1 LNPEP MCL1 NUMA1 POT1 RNF146 SH3BP5 TERF1 TNIK TNKS1BP1 TNKS2 VPS33A	8 interactors: FATE1 FHOD1 REL SLC2A4 SMAD9 TCF4 TNKS TNKS2
Entrez ID		8658	4012
HPRD ID		04490	01041
Ensembl ID		ENSG00000173273	ENSG00000113441
Uniprot IDs		E7EQ52 O95271	Q9UIQ6
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Telomerase Activity Negative Regulation Of Telomere Maintenance Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomerase Activity Regulation Of DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway Protein Polyubiquitination Organelle Organization Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Positive Regulation Of Signal Transduction Positive Regulation Of DNA Strand Elongation Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Replication Homeostatic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Telomere Maintenance Via Telomere Shortening Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Helicase Activity Protein Localization Regulation Of Cellular Component Organization Positive Regulation Of Telomerase Activity	Positive Regulation Of Telomere Maintenance Via Telomerase Protein Auto-ADP-ribosylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Protein ADP-ribosylation Regulation Of Canonical Wnt Signaling Pathway Protein Localization To Chromosome Regulation Of Transcription From RNA Polymerase II Promoter Wnt Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Wnt Signaling Pathway Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Carbohydrate Metabolic Process Positive Regulation Of DNA Replication Positive Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Amylopectin Biosynthetic Process Protein Localization To Organelle Biosynthetic Process Multicellular Organism Growth Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA Replication Fat Cell Differentiation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Positive Regulation Of DNA Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Protein Poly-ADP-ribosylation Positive Regulation Of Wnt Signaling Pathway Protein Polyubiquitination Maintenance Of DNA Repeat Elements Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Glucose Homeostasis Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of Organelle Organization Embryonic Genitalia Morphogenesis Mullerian Duct Regression Myoblast Fate Commitment
Tagcloud ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tnks2 tsnps ucp1 uncorrected variation	aminopeptidase compensated cystinyl disrupts evolutionarily feline footprint genetics hanging heterozygotes inc inked intron juvenile ko leucyl lexicon littermates lix1 mating mendelian muscular neuromuscular neuron recessive rodent rotarod sma transcript
Tagcloud (Difference) ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tnks2 tsnps ucp1 uncorrected variation	aminopeptidase compensated cystinyl disrupts evolutionarily feline footprint genetics hanging heterozygotes inc inked intron juvenile ko leucyl lexicon littermates lix1 mating mendelian muscular neuromuscular neuron recessive rodent rotarod sma transcript
Tagcloud (Intersection) ?