TNKS and TNKS2

Number of citations of the paper that reports this interaction (PMID 11802774)
27

Data Source:
HPRD (in vitro, in vivo)

		TNKS	TNKS2
Gene Name		tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Centromeric Region Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Spindle Pole Nuclear Pore Golgi Apparatus Cytosol Nuclear Membrane	Golgi Membrane Pericentriolar Material Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding	NAD+ ADP-ribosyltransferase Activity Protein Binding Enzyme Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Mitotic Nuclear Division Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Transport Spindle Assembly Cell Division Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Polyubiquitination Protein ADP-ribosylation Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Multicellular Organism Growth Regulation Of Multicellular Organism Growth Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)
Protein-Protein Interactions		14 interactors: DISC1 FANCD2 FNBP1 LNPEP MCL1 NUMA1 POT1 RNF146 SH3BP5 TERF1 TNIK TNKS1BP1 TNKS2 VPS33A	8 interactors: GRB14 LNPEP MAPK1 SH3BP2 TERF1 TNKS TNKS1BP1 ZNF512B
Entrez ID		8658	80351
HPRD ID		04490	06182
Ensembl ID		ENSG00000173273	ENSG00000107854
Uniprot IDs		E7EQ52 O95271	Q9H2K2
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Telomerase Activity Negative Regulation Of Telomere Maintenance Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomerase Activity Regulation Of DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway Protein Polyubiquitination Organelle Organization Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Positive Regulation Of Signal Transduction Positive Regulation Of DNA Strand Elongation Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Replication Homeostatic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Telomere Maintenance Via Telomere Shortening Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Helicase Activity Protein Localization Regulation Of Cellular Component Organization Positive Regulation Of Telomerase Activity	Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Peptidyl-threonine Phosphorylation Telomere Maintenance Positive Regulation Of Signal Transduction MAPK Import Into Nucleus Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Peptidyl-serine Phosphorylation Regulation Of DNA Replication Telomeric Loop Formation Age-dependent Telomere Shortening Protein Poly-ADP-ribosylation Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Shortening Regulation Of Golgi Inheritance Protein Auto-ADP-ribosylation Protein Polyubiquitination Caveolin-mediated Endocytosis Cytosine Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Regulation Of Golgi Organization Positive Regulation Of Telomere Maintenance Regulation Of Organelle Organization Cellular Macromolecule Biosynthetic Process Replicative Cell Aging Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Macromolecule Biosynthetic Process Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Negative Regulation Of Telomere Maintenance DNA Replication Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Microtubule Polymerization Mitotic Nuclear Division Regulation Of Telomerase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation ERK1 And ERK2 Cascade
Tagcloud ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tnks2 tsnps ucp1 uncorrected variation	abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp parp1 parp2 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 valuable
Tagcloud (Difference) ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tsnps ucp1 uncorrected variation	abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp parp1 parp2 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 valuable
Tagcloud (Intersection) ?		tnks2