LNPEP and FAM210B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LNPEP	FAM210B
Description		leucyl and cystinyl aminopeptidase	family with sequence similarity 210 member B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Lumen Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	Aminopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Cell-cell Signaling Female Pregnancy Regulation Of Blood Pressure Neuropeptide Catabolic Process Protein Catabolic Process Negative Regulation Of Cold-induced Thermogenesis	Inflammatory Response Cell Differentiation Erythrocyte Differentiation Erythrocyte Maturation Skin Development Positive Regulation Of Erythrocyte Differentiation Spleen Development Cellular Response To Estradiol Stimulus Reactive Oxygen Species Metabolic Process
Pathways		Endosomal/Vacuolar pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187) Birdshot chorioretinopathy ( 24957906) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		37 interacting genes: AGT AQP6 ASGR2 BIK CD79A CGRRF1 CTAG1A CTAG1B CYB5R3 FAM210B FATE1 FCER1G FHOD1 FKBP7 GGT7 GPR42 GPX8 LCN2 LHFPL5 MMGT1 REEP4 REL SLC10A1 SLC2A4 SLC35E3 SLC39A9 SMAD9 SSMEM1 STOM TAS2R19 TCF4 TLCD4 TMEM35A TNKS TNKS2 UBQLN1 UNC93A	66 interacting genes: ADGRE2 APOL2 ATP6V0B ATP6V0C BCL2L13 BET1 C1GALT1 C5orf46 CCDC167 CD300C CLDND2 CNIH3 CYB5B CYB5R3 CYP4F2 EMP3 FIS1 FXYD6-FXYD2 GIMAP5 HEXB HMOX1 HMOX2 IER3IP1 IFITM3 INSIG2 LNPEP LPAR3 MFF MS4A13 NINJ2 NKG7 ORMDL2 OTOP3 PLP2 PLPP6 RPRM RTP2 SERP1 SERP2 SLC16A13 SLC30A8 SLC35B4 SLC35G1 SMCO4 SMIM1 STATH STX6 STX7 SYNJ2BP TF TFRC TIMM23 TIMMDC1 TMEM107 TMEM11 TMEM140 TMEM187 TMEM19 TMIE UBE2J1 VAMP1 VAMP3 VAMP4 VKORC1 YIF1A ZDHHC21
Entrez ID		4012	116151
HPRD ID		01041	12737
Ensembl ID		ENSG00000113441	ENSG00000124098
Uniprot IDs		Q9UIQ6	Q96KR6
PDB IDs		4P8Q 4PJ6 4Z7I 5C97 5JHQ 5MJ6 7ZYF 8CGP 8CGW 8P0I
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Telomere Capping	Membrane Endoplasmic Reticulum Membrane SNARE Complex SNAP Receptor Activity Golgi Membrane Establishment Of Protein Localization Endoplasmic Reticulum Mitochondrial Outer Membrane Heme Oxidation Heme Oxygenase (decyclizing) Activity SNARE Complex Assembly Organelle Fusion Protein Binding Intracellular Chemical Homeostasis Nitric-oxide Synthase Complex Vesicle Fusion Synaptic Vesicle To Endosome Fusion Transport Vesicle Organelle Membrane Fusion Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Chemical Homeostasis Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Intracellular Monoatomic Cation Homeostasis Nitrite Reductase (NO-forming) Activity Multicellular Organismal-level Iron Ion Homeostasis Clathrin-coated Endocytic Vesicle Membrane Protein Targeting Multicellular Organismal-level Chemical Homeostasis Cellular Homeostasis Intracellular Monoatomic Ion Homeostasis Recycling Endosome Protein Targeting To Mitochondrion Nitric Oxide Metabolic Process Plasma Membrane Reactive Nitrogen Species Metabolic Process Membrane Fusion Cholesterol Biosynthetic Process HFE-transferrin Receptor Complex Negative Regulation Of Fatty Acid Transport Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Sterol Biosynthetic Process Bleb Assembly Heme Catabolic Process Response To Type II Interferon Golgi Vesicle Transport Azurophil Granule Protein Transport
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