TNKS and TNKS1BP1

Number of citations of the paper that reports this interaction (PMID 11854288)
32

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TNKS	TNKS1BP1
Gene Name		tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	tankyrase 1 binding protein 1, 182kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Centromeric Region Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Spindle Pole Nuclear Pore Golgi Apparatus Cytosol Nuclear Membrane	Nucleus Nucleoplasm Nuclear Telomeric Heterochromatin Cytoplasm Cytosol Cytoskeleton Plasma Membrane CCR4-NOT Complex
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding	Enzyme Binding Ankyrin Binding
	Biological Process	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Mitotic Nuclear Division Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Transport Spindle Assembly Cell Division Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Telomere Maintenance Via Telomerase Gene Expression
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)
Protein-Protein Interactions		14 interactors: DISC1 FANCD2 FNBP1 LNPEP MCL1 NUMA1 POT1 RNF146 SH3BP5 TERF1 TNIK TNKS1BP1 TNKS2 VPS33A	3 interactors: CSNK2A1 TNKS TNKS2
Entrez ID		8658	85456
HPRD ID		04490	06164
Ensembl ID		ENSG00000173273	ENSG00000149115
Uniprot IDs		E7EQ52 O95271	Q9C0C2
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Telomerase Activity Negative Regulation Of Telomere Maintenance Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomerase Activity Regulation Of DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway Protein Polyubiquitination Organelle Organization Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Positive Regulation Of Signal Transduction Positive Regulation Of DNA Strand Elongation Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Replication Homeostatic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Telomere Maintenance Via Telomere Shortening Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Helicase Activity Protein Localization Regulation Of Cellular Component Organization Positive Regulation Of Telomerase Activity	Positive Regulation Of Telomere Maintenance Via Telomerase Protein Auto-ADP-ribosylation Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Wnt Signaling Pathway Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Protein ADP-ribosylation Protein Localization To Chromosome Positive Regulation Of DNA Replication Regulation Of Organelle Organization Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Protein Poly-ADP-ribosylation Regulation Of Cellular Component Organization Macromolecule Glycosylation Protein Glycosylation Glycosylation Glycoprotein Biosynthetic Process Positive Regulation Of Organelle Organization Glycoprotein Metabolic Process Protein Localization To Organelle Regulation Of Signal Transduction Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Growth Regulation Of Signaling Cell Surface Receptor Signaling Pathway Mitotic Cell Cycle Process Cellular Protein Modification Process Mitotic Cell Cycle Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Mitotic Spindle Organization Cell Cycle Process Carbohydrate Metabolic Process Negative Regulation Of DNA Binding Peptidyl-threonine Phosphorylation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation
Tagcloud ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tnks2 tsnps ucp1 uncorrected variation
Tagcloud (Difference) ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tnks2 tsnps ucp1 uncorrected variation
Tagcloud (Intersection) ?