LNPEP and CYB5R3

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		LNPEP	CYB5R3
Description		leucyl and cystinyl aminopeptidase	cytochrome b5 reductase 3
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GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Lumen Perinuclear Region Of Cytoplasm	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Aminopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding
	Biological Process	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Cell-cell Signaling Female Pregnancy Regulation Of Blood Pressure Neuropeptide Catabolic Process Protein Catabolic Process Negative Regulation Of Cold-induced Thermogenesis	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process
Pathways		Endosomal/Vacuolar pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane Antigen processing: Ubiquitination & Proteasome degradation	Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			NADH Flavin adenine dinucleotide Copper
Diseases			Methemoglobinemia
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187) Birdshot chorioretinopathy ( 24957906) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)	Initial pursuit acceleration ( 29064472)
Interacting Genes		37 interacting genes: AGT AQP6 ASGR2 BIK CD79A CGRRF1 CTAG1A CTAG1B CYB5R3 FAM210B FATE1 FCER1G FHOD1 FKBP7 GGT7 GPR42 GPX8 LCN2 LHFPL5 MMGT1 REEP4 REL SLC10A1 SLC2A4 SLC35E3 SLC39A9 SMAD9 SSMEM1 STOM TAS2R19 TCF4 TLCD4 TMEM35A TNKS TNKS2 UBQLN1 UNC93A	78 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 YIPF4 ZDHHC15
Entrez ID		4012	1727
HPRD ID		01041	08942
Ensembl ID		ENSG00000113441	ENSG00000100243
Uniprot IDs		Q9UIQ6	P00387
PDB IDs		4P8Q 4PJ6 4Z7I 5C97 5JHQ 5MJ6 7ZYF 8CGP 8CGW 8P0I	1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Telomere Capping	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport
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