LNPEP and TAS2R19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LNPEP	TAS2R19
Description		leucyl and cystinyl aminopeptidase	taste 2 receptor member 19
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Lumen Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Aminopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity	G Protein-coupled Receptor Activity Protein Binding Bitter Taste Receptor Activity
	Biological Process	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Proteolysis Cell-cell Signaling Female Pregnancy Regulation Of Blood Pressure Neuropeptide Catabolic Process Protein Catabolic Process Negative Regulation Of Cold-induced Thermogenesis	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Taste
Pathways		Endosomal/Vacuolar pathway Translocation of SLC2A4 (GLUT4) to the plasma membrane Antigen processing: Ubiquitination & Proteasome degradation	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187) Birdshot chorioretinopathy ( 24957906) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494)
Interacting Genes		37 interacting genes: AGT AQP6 ASGR2 BIK CD79A CGRRF1 CTAG1A CTAG1B CYB5R3 FAM210B FATE1 FCER1G FHOD1 FKBP7 GGT7 GPR42 GPX8 LCN2 LHFPL5 MMGT1 REEP4 REL SLC10A1 SLC2A4 SLC35E3 SLC39A9 SMAD9 SSMEM1 STOM TAS2R19 TCF4 TLCD4 TMEM35A TNKS TNKS2 UBQLN1 UNC93A	7 interacting genes: LNPEP MMGT1 PGRMC2 PVR TMEM14B TMEM167B TYW1B
Entrez ID		4012	259294
HPRD ID		01041	18156
Ensembl ID		ENSG00000113441	ENSG00000212124
Uniprot IDs		Q9UIQ6	P59542
PDB IDs		4P8Q 4PJ6 4Z7I 5C97 5JHQ 5MJ6 7ZYF 8CGP 8CGW 8P0I
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Telomere Capping	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Iron Ion Transport TRNA-4-demethylwyosine Synthase Activity Susceptibility To T Cell Mediated Cytotoxicity Cobalt Ion Transmembrane Transporter Activity Early Endosome Lumen Neuropeptide Catabolic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Susceptibility To Natural Killer Cell Mediated Cytotoxicity Heme Transmembrane Transporter Activity Heme Transport Constitutive Secretory Pathway Inorganic Cation Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Wybutosine Biosynthetic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence EMC Complex Cobalt Ion Transport
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