TNKS and HNRNPM

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		TNKS	HNRNPM
Description		tankyrase	heterogeneous nuclear ribonucleoprotein M
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GO Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Spindle Pole Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Membrane Nuclear Body Nuclear Membrane Mitotic Spindle Pole	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Membrane Nuclear Matrix Paraspeckles Synapse Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Telomerase Inhibitor Activity Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Histone Binding Metal Ion Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding
	Biological Process	Protein Polyubiquitination Mitotic Spindle Organization Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Spindle Assembly Cell Division Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		A body shape index ( 34021172) Acne (severe) ( 24927181) Age at first birth ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874) Bipolar disorder ( 31043756) Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Joint mobility (Beighton score) ( 27182965) LDL cholesterol levels ( 32203549) Metabolite levels ( 22916037) Mosquito bite size ( 28199695) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Schizophrenia ( 26198764) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Appendicular lean mass ( 33097823) Coronary artery disease ( 29212778)
Interacting Genes		34 interacting genes: ADPRS ANKRD28 AXIN1 CACNA1S CDKN1A DTNBP1 EIF4A1 ENDOG EPM2AIP1 FANCD2 FNBP1 GMDS HNRNPM INPP5K LNPEP MAVS MCL1 NELFE NUMA1 OARD1 PLCH2 POT1 PTEN RNF146 RUNDC1 SDCBP TCL1A TERF1 TNIK TNKS1BP1 TNKS2 UBASH3B USP25 VPS33A	117 interacting genes: AKAP9 APC CDC5L CEACAM5 DUX4 ECPAS FXR1 FXR2 GMCL2 GSK3A GSK3B HGS HNRNPF HNRNPH1 JUN LENG8 LINC00624 LMO1 LMO2 LMO3 LONRF2 LYST MAGEA6 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PLRG1 PRRC2A RBM4 RBM4B SMARCB1 STAT3 SUMO2 TCERG1 TEKT4 TNKS TRAF1 TSC1 TSGA10 U2AF1 UBC UBE2I USP7 WDR77 WEE2-AS1 YWHAG ZNF207
Entrez ID		8658	4670
HPRD ID		04490	01188
Ensembl ID		ENSG00000173273	ENSG00000099783
Uniprot IDs		H0YAW5 O95271	P52272 Q59ES8
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S 4W6E 5EBT 5ECE 5ETY 5GP7 5JHQ 5JTI 5JU5 5KNI 6QXU 6URQ 7KKM 7KKN 7KKO 7KKP 7KKQ 7OCV 8X5J	2DGV 2DH9 2DO0 2OT8
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Protein Serine/threonine Kinase Binding Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening O-acetyl-ADP-ribose Deacetylase Activity Positive Regulation Of Cellular Component Organization Chromosome Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Shelterin Complex Protein De-ADP-ribosylation Regulation Of Signal Transduction Ankyrin Repeat Binding Regulation Of Telomere Maintenance Via Telomerase In Utero Embryonic Development Organelle Organization Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Component Organization Embryo Development Ending In Birth Or Egg Hatching Chordate Embryonic Development Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Multicellular Organism Development Positive Regulation Of DNA Metabolic Process Protein Polyubiquitination Telomeric Loop Disassembly Telomere Capping Perinuclear Region Of Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Cytoplasm Positive Regulation Of Organelle Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Chromosome Organization Macromolecule Metabolic Process Nuclear Body DNA Damage Response Hydrolase Activity Cellular Response To Oxidative Stress	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization Positive Regulation Of MRNA Catabolic Process RNA Destabilization Positive Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Cytokine Production Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of MRNA Stability Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of MRNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Response To Growth Factor Stimulus
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