TNKS and USP25

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		TNKS	USP25
Description		tankyrase	ubiquitin specific peptidase 25
Image
GO Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Spindle Pole Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Membrane Nuclear Body Nuclear Membrane Mitotic Spindle Pole	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Telomerase Inhibitor Activity Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Histone Binding Metal Ion Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding Deubiquitinase Activity
	Biological Process	Protein Polyubiquitination Mitotic Spindle Organization Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Spindle Assembly Cell Division Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Oxidative Stress Protein Modification Process Interleukin-17A-mediated Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Response To Oxidative Stress Negative Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of ERAD Pathway
Pathways		TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity	Ub-specific processing proteases
Drugs
Diseases
GWAS		A body shape index ( 34021172) Acne (severe) ( 24927181) Age at first birth ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874) Bipolar disorder ( 31043756) Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Joint mobility (Beighton score) ( 27182965) LDL cholesterol levels ( 32203549) Metabolite levels ( 22916037) Mosquito bite size ( 28199695) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Schizophrenia ( 26198764) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		34 interacting genes: ADPRS ANKRD28 AXIN1 CACNA1S CDKN1A DTNBP1 EIF4A1 ENDOG EPM2AIP1 FANCD2 FNBP1 GMDS HNRNPM INPP5K LNPEP MAVS MCL1 NELFE NUMA1 OARD1 PLCH2 POT1 PTEN RNF146 RUNDC1 SDCBP TCL1A TERF1 TNIK TNKS1BP1 TNKS2 UBASH3B USP25 VPS33A	37 interacting genes: ACTA1 ARMC8 CDC73 CNTN1 EIF4A3 FBXL17 FLNC GAPDH GDI1 MAGEB4 MAVS MID2 MT2A NAP1L3 PAX6 PUS10 RAD23A RAD23B RPS10-NUDT3 RSL1D1 SENP1 SKIL SNRNP70 SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS TNKS2 TUBB UBC UBE2I VPS45 YARS1 ZNF426 ZNF841
Entrez ID		8658	29761
HPRD ID		04490	05296
Ensembl ID		ENSG00000173273	ENSG00000155313
Uniprot IDs		H0YAW5 O95271	Q9UHP3
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S 4W6E 5EBT 5ECE 5ETY 5GP7 5JHQ 5JTI 5JU5 5KNI 6QXU 6URQ 7KKM 7KKN 7KKO 7KKP 7KKQ 7OCV 8X5J	2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Protein Serine/threonine Kinase Binding Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening O-acetyl-ADP-ribose Deacetylase Activity Positive Regulation Of Cellular Component Organization Chromosome Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Shelterin Complex Protein De-ADP-ribosylation Regulation Of Signal Transduction Ankyrin Repeat Binding Regulation Of Telomere Maintenance Via Telomerase In Utero Embryonic Development Organelle Organization Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Component Organization Embryo Development Ending In Birth Or Egg Hatching Chordate Embryonic Development Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Multicellular Organism Development Positive Regulation Of DNA Metabolic Process Protein Polyubiquitination Telomeric Loop Disassembly Telomere Capping Perinuclear Region Of Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Cytoplasm Positive Regulation Of Organelle Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Chromosome Organization Macromolecule Metabolic Process Nuclear Body DNA Damage Response Hydrolase Activity Cellular Response To Oxidative Stress	Presynaptic Cytosol Protein Tag Activity Protein Sumoylation Postsynaptic Cytosol Nucleus Post-translational Protein Modification Protein Modification By Small Protein Conjugation PML Body Protein Poly-ADP-ribosylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding Positive Regulation Of Telomere Capping Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Glutamatergic Synapse Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Regulation Of Telomere Capping Protein Localization To Organelle Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Cytosol Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Proteasome Binding Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-specific Protease Binding Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding Nuclear Pore NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Response To Cytokine
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