TNKS and ANKRD28

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		TNKS	ANKRD28
Description		tankyrase	ankyrin repeat domain 28
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Spindle Pole Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Membrane Nuclear Body Nuclear Membrane Mitotic Spindle Pole	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Serine/threonine Phosphatase Complex Lamellipodium Cell Projection
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Telomerase Inhibitor Activity Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Histone Binding Metal Ion Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Protein Polyubiquitination Mitotic Spindle Organization Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Spindle Assembly Cell Division Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric	Positive Regulation Of Focal Adhesion Assembly
Pathways		TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity	Telomere Extension By Telomerase COPII-mediated vesicle transport
Drugs
Diseases
GWAS		A body shape index ( 34021172) Acne (severe) ( 24927181) Age at first birth ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874) Bipolar disorder ( 31043756) Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Joint mobility (Beighton score) ( 27182965) LDL cholesterol levels ( 32203549) Metabolite levels ( 22916037) Mosquito bite size ( 28199695) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Schizophrenia ( 26198764) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Refractive error ( 32231278)
Interacting Genes		34 interacting genes: ADPRS ANKRD28 AXIN1 CACNA1S CDKN1A DTNBP1 EIF4A1 ENDOG EPM2AIP1 FANCD2 FNBP1 GMDS HNRNPM INPP5K LNPEP MAVS MCL1 NELFE NUMA1 OARD1 PLCH2 POT1 PTEN RNF146 RUNDC1 SDCBP TCL1A TERF1 TNIK TNKS1BP1 TNKS2 UBASH3B USP25 VPS33A	34 interacting genes: ABCF2 AGPAT2 ANK2 ANKRD26 ANKRD50 BCL3 BRCA1 CCDC187 CD164 CSNK2B EEF1G EHMT2 EIF3D GADD45GIP1 HNRNPK HNRNPR INCA1 KCNV2 MYOM1 NOTCH2 NOTCH3 PIBF1 PTRH1 RNF11 TGM2 TGS1 THAP7 TMIE TNKS TNKS2 TTN UACA YTHDC1 ZNF512B
Entrez ID		8658	23243
HPRD ID		04490	10651
Ensembl ID		ENSG00000173273	ENSG00000206560
Uniprot IDs		H0YAW5 O95271	O15084
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S 4W6E 5EBT 5ECE 5ETY 5GP7 5JHQ 5JTI 5JU5 5KNI 6QXU 6URQ 7KKM 7KKN 7KKO 7KKP 7KKQ 7OCV 8X5J
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Protein Serine/threonine Kinase Binding Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening O-acetyl-ADP-ribose Deacetylase Activity Positive Regulation Of Cellular Component Organization Chromosome Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Shelterin Complex Protein De-ADP-ribosylation Regulation Of Signal Transduction Ankyrin Repeat Binding Regulation Of Telomere Maintenance Via Telomerase In Utero Embryonic Development Organelle Organization Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Component Organization Embryo Development Ending In Birth Or Egg Hatching Chordate Embryonic Development Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Multicellular Organism Development Positive Regulation Of DNA Metabolic Process Protein Polyubiquitination Telomeric Loop Disassembly Telomere Capping Perinuclear Region Of Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Cytoplasm Positive Regulation Of Organelle Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Chromosome Organization Macromolecule Metabolic Process Nuclear Body DNA Damage Response Hydrolase Activity Cellular Response To Oxidative Stress	M Band Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Telomere Capping Glomerular Capillary Formation Enzyme Binding Marginal Zone B Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Heterochromatin Formation Cellular Response To Cocaine Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation Protein Kinase A Signaling NAD+-protein-glutamate ADP-ribosyltransferase Activity Random Inactivation Of X Chromosome NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Capping C2H2 Zinc Finger Domain Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Kinase Regulator Activity Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Poly-ADP-ribosylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Peptidyl-threonine Phosphorylation NAD+-protein Mono-ADP-ribosyltransferase Activity Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening NAD+ Poly-ADP-ribosyltransferase Activity Negative Regulation Of Receptor Signaling Pathway Via STAT Mature B Cell Differentiation Involved In Immune Response Protein Localization To T-tubule Nucleoplasm Bcl3-Bcl10 Complex Mature B Cell Differentiation Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
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