TNKS and RNF146

Number of citations of the paper that reports this interaction (PMID 25327252)
0

Data Source:
BioGRID (pull down)

		TNKS	RNF146
Gene Name		tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	ring finger protein 146
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Centromeric Region Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Spindle Pole Nuclear Pore Golgi Apparatus Cytosol Nuclear Membrane	Nucleus Cytosol
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly-ADP-D-ribose Binding
	Biological Process	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Mitotic Nuclear Division Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Transport Spindle Assembly Cell Division Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway	Wnt Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)	Breast cancer ( 18326623) Intracranial volume ( 22504418)
Protein-Protein Interactions		14 interactors: DISC1 FANCD2 FNBP1 LNPEP MCL1 NUMA1 POT1 RNF146 SH3BP5 TERF1 TNIK TNKS1BP1 TNKS2 VPS33A	12 interactors: CCDC155 PARP1 PFN2 TGFBR1 TNKS TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6
Entrez ID		8658	81847
HPRD ID		04490	11511
Ensembl ID		ENSG00000173273	ENSG00000118518
Uniprot IDs		E7EQ52 O95271	Q9NTX7
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8	2D8T 3V3L
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Telomerase Activity Negative Regulation Of Telomere Maintenance Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomerase Activity Regulation Of DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway Protein Polyubiquitination Organelle Organization Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Positive Regulation Of Signal Transduction Positive Regulation Of DNA Strand Elongation Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Replication Homeostatic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Telomere Maintenance Via Telomere Shortening Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Helicase Activity Protein Localization Regulation Of Cellular Component Organization Positive Regulation Of Telomerase Activity	Protein Polyubiquitination Protein Poly-ADP-ribosylation Protein K48-linked Ubiquitination Protein Ubiquitination Regulation Of Binding Protein Modification By Small Protein Conjugation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Cellular Response To Stress Double-strand Break Repair Protein ADP-ribosylation DNA Repair Protein Catabolic Process Peptidyl-threonine Phosphorylation Cellular Protein Modification Process TRIF-dependent Toll-like Receptor Signaling Pathway Base-excision Repair MyD88-independent Toll-like Receptor Signaling Pathway Response To Stress Protein Glycosylation Macromolecule Glycosylation Toll-like Receptor 3 Signaling Pathway Chromosome Localization To Nuclear Envelope Involved In Synapsis Cellular Response To DNA Damage Stimulus Glycosylation Telomere Maintenance Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Glycoprotein Biosynthetic Process Regulation Of DNA Binding Positive Regulation Of Protein Import Into Nucleus Cellular Response To Reactive Oxygen Species Glycoprotein Metabolic Process Regulation Of Cellular Localization Cell Cycle Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Toll-like Receptor Signaling Pathway DNA Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Hyperosmotic Salinity Response Regulation Of Growth Rate Regulation Of Cell Projection Assembly Peptidyl-serine Phosphorylation Positive Regulation Of Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Auto-ADP-ribosylation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction
Tagcloud ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tnks2 tsnps ucp1 uncorrected variation	adp ation axin biology catenin cdk4 classical cyclind1 cycline downregulated e3 enhancing finger g0 invasiveness ligase ligation lymphatic metalloproteinases nsclc promoted ptnm rarely restricted ribosyl staging summary transitions ubiquitin
Tagcloud (Difference) ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tnks2 tsnps ucp1 uncorrected variation	adp ation axin biology catenin cdk4 classical cyclind1 cycline downregulated e3 enhancing finger g0 invasiveness ligase ligation lymphatic metalloproteinases nsclc promoted ptnm rarely restricted ribosyl staging summary transitions ubiquitin
Tagcloud (Intersection) ?