TNKS

Gene Name		tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Pericentriolar Material Chromosome, Centromeric Region Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Spindle Pole Nuclear Pore Golgi Apparatus Cytosol Nuclear Membrane
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Mitotic Nuclear Division Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Transport Spindle Assembly Cell Division Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)
Protein-protein Interactions		14 interactors: DISC1 FANCD2 FNBP1 LNPEP MCL1 NUMA1 POT1 RNF146 SH3BP5 TERF1 TNIK TNKS1BP1 TNKS2 VPS33A
Entrez ID		8658
HPRD ID		04490
Ensembl ID		ENSG00000173273
Uniprot IDs		E7EQ52 O95271
PDB IDs		2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Telomerase Activity Negative Regulation Of Telomere Maintenance Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomerase Activity Regulation Of DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway Protein Polyubiquitination Organelle Organization Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Positive Regulation Of Signal Transduction Positive Regulation Of DNA Strand Elongation Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Positive Regulation Of DNA Replication Homeostatic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase G2/M Transition Of Mitotic Cell Cycle Chromosome Organization Telomere Maintenance Via Telomere Shortening Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Helicase Activity Protein Localization Regulation Of Cellular Component Organization Positive Regulation Of Telomerase Activity
Tagcloud ?		acd additive assuming caucasian corroborated eleven elusive haplotype haplotypes incident leukocyte multivariable pot1 prespecified shortening t2d tagging telomere tep1 terc terf1 terf2 terf2ip tert tnks2 tsnps ucp1 uncorrected variation