ANKRD28 and ANK2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ANKRD28	ANK2
Description		ankyrin repeat domain 28	ankyrin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Serine/threonine Phosphatase Complex Lamellipodium Cell Projection	Cytoplasm Mitochondrion Lysosome Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Synapse Postsynaptic Membrane Recycling Endosome
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding ATPase Binding Channel Activator Activity Potassium Channel Activator Activity Phosphorylation-dependent Protein Binding
	Biological Process	Positive Regulation Of Focal Adhesion Assembly	Regulation Of Heart Rate Atrial Septum Development Intracellular Calcium Ion Homeostasis Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Intracellular Protein Localization Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Protein Transport Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Cell Surface Protein Localization To M-band Protein Localization To T-tubule Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Import Across Plasma Membrane
Pathways		Telomere Extension By Telomerase COPII-mediated vesicle transport	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport
Drugs
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Refractive error ( 32231278)	Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971) Chronotype ( 30696823) Diastolic blood pressure ( 31469255) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Coprococcus) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Parkinson's disease ( 28892059) Periventricular white matter hyperintensities ( 32517579) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		34 interacting genes: ABCF2 AGPAT2 ANK2 ANKRD26 ANKRD50 BCL3 BRCA1 CCDC187 CD164 CSNK2B EEF1G EHMT2 EIF3D GADD45GIP1 HNRNPK HNRNPR INCA1 KCNV2 MYOM1 NOTCH2 NOTCH3 PIBF1 PTRH1 RNF11 TGM2 TGS1 THAP7 TMIE TNKS TNKS2 TTN UACA YTHDC1 ZNF512B	21 interacting genes: ANKRD28 DNAJB1 DNAJB5 ECPAS EPB42 GABARAP GABARAPL1 GABARAPL2 L1CAM MAP1LC3A MAP1LC3B MAP1LC3C NDEL1 NRCAM OBSCN RIPK4 SIGMAR1 SPTBN1 TAF9 TNIK TP53
Entrez ID		23243	287
HPRD ID		10651	00110
Ensembl ID		ENSG00000206560	ENSG00000145362
Uniprot IDs		O15084	A0A5F9ZGS5 A0A5F9ZGY1 A0A5F9ZGZ1 A0A5F9ZH03 A0A5F9ZH10 A0A5F9ZH17 A0A5F9ZH18 A0A5F9ZH34 A0A5F9ZH39 A0A5F9ZH58 A0A5F9ZH70 A0A5F9ZH99 A0A5F9ZHE2 A0A5F9ZHJ4 A0A5F9ZHJ6 A0A5F9ZHL3 A0A5F9ZHL9 A0A5F9ZHN0 A0A5F9ZHQ3 A0A5F9ZHR2 A0A5F9ZHY6 A0A5F9ZI08 A0A5F9ZI16 A0A5F9ZI36 A0A5F9ZI53 A0A5F9ZI56 A0A5F9ZI69 A0A5F9ZI81 E9PCH6 H0Y933 Q01484
PDB IDs			4D8O 4RLV 4RLY 5Y4D 5Y4E 5Y4F 5YIR 5YIS 6KZJ 6M3Q 8ZE8
Enriched GO Terms of Interacting Partners?		M Band Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Telomere Capping Glomerular Capillary Formation Enzyme Binding Marginal Zone B Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Heterochromatin Formation Cellular Response To Cocaine Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation Protein Kinase A Signaling NAD+-protein-glutamate ADP-ribosyltransferase Activity Random Inactivation Of X Chromosome NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Capping C2H2 Zinc Finger Domain Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Kinase Regulator Activity Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Poly-ADP-ribosylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Peptidyl-threonine Phosphorylation NAD+-protein Mono-ADP-ribosyltransferase Activity Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening NAD+ Poly-ADP-ribosyltransferase Activity Negative Regulation Of Receptor Signaling Pathway Via STAT Mature B Cell Differentiation Involved In Immune Response Protein Localization To T-tubule Nucleoplasm Bcl3-Bcl10 Complex Mature B Cell Differentiation Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Autophagosome Maturation Autophagosome Membrane Phospholipid Binding Autophagosome Macroautophagy Autophagosome Assembly Cellular Response To Starvation Autophagosome Organization Response To Starvation Cellular Response To Nutrient Levels Protein-containing Complex Disassembly Autophagy Ubiquitin Protein Ligase Binding Vacuole Organization Beta-tubulin Binding Cytoskeleton GABA Receptor Binding Response To Nutrient Levels Ankyrin Binding Protein-containing Complex Organization Microtubule Cytoplasmic Vesicle Cellular Component Assembly Cellular Response To Stress Organelle Organization Microtubule Binding Organelle Membrane Cytosol Glutamatergic Synapse ATPase Binding System Development Organelle Assembly Protein-folding Chaperone Binding Endomembrane System M Band Response To Stress Cortical Cytoskeleton Negative Regulation Of Proteolysis Regulation Of ATP-dependent Activity Central Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cytoskeleton Organization Microtubule Associated Complex Regulation Of Proteolysis Cytoplasm Negative Regulation Of Helicase Activity
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