ANKRD28 and TNKS2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ANKRD28	TNKS2
Description		ankyrin repeat domain 28	tankyrase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Serine/threonine Phosphatase Complex Lamellipodium Cell Projection	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Nucleus Nuclear Envelope Chromosome Cytoplasm Golgi Apparatus Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Metal Ion Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Positive Regulation Of Focal Adhesion Assembly	Protein Polyubiquitination Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		Telomere Extension By Telomerase COPII-mediated vesicle transport	TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Refractive error ( 32231278)	Appendicular lean mass ( 33097823) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver volume ( 34128465) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		34 interacting genes: ABCF2 AGPAT2 ANK2 ANKRD26 ANKRD50 BCL3 BRCA1 CCDC187 CD164 CSNK2B EEF1G EHMT2 EIF3D GADD45GIP1 HNRNPK HNRNPR INCA1 KCNV2 MYOM1 NOTCH2 NOTCH3 PIBF1 PTRH1 RNF11 TGM2 TGS1 THAP7 TMIE TNKS TNKS2 TTN UACA YTHDC1 ZNF512B	17 interacting genes: AMOTL2 ANKRD28 ARAP3 DSCR9 GRB14 LNPEP MAPK1 MAVS MDC1 PTEN SASH1 SH3BP2 TERF1 TNKS TNKS1BP1 USP25 ZNF512B
Entrez ID		23243	80351
HPRD ID		10651	06182
Ensembl ID		ENSG00000206560	ENSG00000107854
Uniprot IDs		O15084	Q9H2K2
PDB IDs			2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT 5OWS 5OWT 6TG4 6TKM 6TKN 6TKP 6TKQ 6TKR 6TKS 7A1S 7O6X 7POX 7R3Z 8ALY
Enriched GO Terms of Interacting Partners?		M Band Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Telomere Capping Glomerular Capillary Formation Enzyme Binding Marginal Zone B Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Heterochromatin Formation Cellular Response To Cocaine Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation Protein Kinase A Signaling NAD+-protein-glutamate ADP-ribosyltransferase Activity Random Inactivation Of X Chromosome NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Capping C2H2 Zinc Finger Domain Binding Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Kinase Regulator Activity Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Poly-ADP-ribosylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Peptidyl-threonine Phosphorylation NAD+-protein Mono-ADP-ribosyltransferase Activity Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening NAD+ Poly-ADP-ribosyltransferase Activity Negative Regulation Of Receptor Signaling Pathway Via STAT Mature B Cell Differentiation Involved In Immune Response Protein Localization To T-tubule Nucleoplasm Bcl3-Bcl10 Complex Mature B Cell Differentiation Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening	Protein Polyubiquitination Ankyrin Repeat Binding Positive Regulation Of Telomere Maintenance Peptidyl-threonine Phosphorylation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Process Telomere Maintenance Via Telomerase Protein Ubiquitination RNA-templated DNA Biosynthetic Process Negative Regulation Of Cell Cycle Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Modification By Small Protein Conjugation Molecular Adaptor Activity Protein Modification Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Response To DsRNA Phosphotyrosine Residue Binding Response To Exogenous DsRNA Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of IP-10 Production Post-translational Protein Modification Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Cytosine Metabolic Process Regulation Of Focal Adhesion Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Regulation Of Epithelial Cell Migration Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Regulation Of Peroxisome Organization Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Interleukin-34-mediated Signaling Pathway Regulation Of Cell-substrate Junction Organization
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