RASGRP4

Description		RAS guanyl releasing protein 4
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Mediated Immunity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Myeloid Cell Differentiation Cell Differentiation Antibacterial Innate Immune Response
Pathways		FCERI mediated NF-kB activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Monocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		6 interacting genes: BNIP2 DYNLL1 HRAS RAP1A SEC22A TMPRSS4
Entrez ID		115727
HPRD ID		09540
Ensembl ID		ENSG00000171777
Uniprot IDs		Q8TDF6
PDB IDs		6AXG
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade GDP Binding G Protein Activity Negative Regulation Of Growth Rate Regulation Of Cellular Localization GTPase Complex Response To Antineoplastic Agent Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Secretory Granule Regulation Of MAPK Cascade Phospholipase C Activator Activity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Localization To Membrane Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Growth Rate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Apoptotic Process Oncogene-induced Cell Senescence Cell Development Guanyl-nucleotide Exchange Factor Complex Cell Death Programmed Cell Death Regulation Of Protein Localization Nitric-oxide Synthase Regulator Activity Positive Regulation Of Intracellular Signal Transduction Spindle Pole Centrosome Response To Oxygen-glucose Deprivation GTPase Activity Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Positive Regulation Of Ruffle Assembly Small GTPase-mediated Signal Transduction T-helper 1 Type Immune Response Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Forskolin Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Nerve Growth Factor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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