RASGRP4 and RAP1A

Number of citations of the paper that reports this interaction (PMID 11880369)
27

Data Source:
HPRD (in vitro)

		RASGRP4	RAP1A
Gene Name		RAS guanyl releasing protein 4	RAP1A, member of RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Ras Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Diacylglycerol Binding GTP-dependent Protein Binding	GTPase Activity Protein Binding GTP Binding Protein Transporter Activity Ras GTPase Binding Rap Guanyl-nucleotide Exchange Factor Activity Protein Complex Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cell Proliferation Response To Extracellular Stimulus Cell Growth Myeloid Cell Differentiation Positive Regulation Of Ras GTPase Activity Positive Regulation Of Ras Protein Signal Transduction	Activation Of MAPKK Activity Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Positive Regulation Of Neuron Projection Development Protein Transport Microvillus Assembly Platelet Activation Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Nerve Growth Factor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Regulation Of Cell Junction Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis
Pathways		FCERI mediated NF-kB activation Fc epsilon receptor (FCERI) signaling Innate Immune System	Signalling to ERKs Signalling by NGF Prolonged ERK activation events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism Regulation of insulin secretion p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling NGF signalling via TRKA from the plasma membrane GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) ARMS-mediated activation Rap1 signalling Platelet activation, signaling and aggregation Frs2-mediated activation Adaptive Immune System
Drugs
Diseases
GWAS			Osteoporosis ( 20548944)
Protein-Protein Interactions		2 interactors: HRAS RAP1A	41 interactors: APBB1IP ARHGEF1 BIN1 BMX BRAF FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A KRIT1 MLLT4 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALA RALGDS RAP1GAP RAP1GDS1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA4 TCEB3 TNFRSF10C
Entrez ID		115727	5906
HPRD ID		09540	01545
Ensembl ID		ENSG00000171777	ENSG00000116473
Uniprot IDs		Q8TDF6	A8KAH9 P62834
PDB IDs			1C1Y 1GUA 3KUC
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cell Projection Organization Regulation Of Synaptic Transmission Blood Coagulation Hemostasis Positive Regulation Of Ras GTPase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Ruffle Assembly Regulation Of Ras GTPase Activity Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Wound Healing Response To Growth Factor Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Rap Protein Signal Transduction Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of MiRNA Metabolic Process Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Vasculogenesis Positive Regulation Of GTPase Activity Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Nerve Growth Factor Signaling Pathway Regulation Of GTPase Activity Regulation Of Kinase Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Actin Cytoskeleton Reorganization Response To Organonitrogen Compound Regulation Of Vasculogenesis Positive Regulation Of Rap GTPase Activity Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway	Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Rap GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Regulation Of Rap Protein Signal Transduction Signal Transduction Cell Communication Regulation Of Metabolic Process Cellular Response To Stimulus Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Ras Protein Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Apoptotic Process Regulation Of Cell Death Cell Activation Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Lyase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Differentiation
Tagcloud ?		6j accelerated aml aml1 bmt c57bl class cloning cmmol conceivable cooperates flt3 hf6 immortalized leukemia leukemic leukemogenesis libraries m2 marrow mll mpd render s291fsx300 screened sept6 transduced transduction transplanted	bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Difference) ?		6j accelerated aml aml1 bmt c57bl class cloning cmmol conceivable cooperates flt3 hf6 immortalized leukemia leukemic leukemogenesis libraries m2 marrow mll mpd render s291fsx300 screened sept6 transduced transduction transplanted	bfa bisphosphonates brefeldin camp cathepsin cdc42 cytoskeletal diminish diminished epac epac1 epac2 esi fak intermediates isoprenylation ko multinucleated nfatc1 nfkb osteoclast osteopontin pctp permit rac1 rankl raw264 rhoa
Tagcloud (Intersection) ?