RASGRP4 and TMPRSS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RASGRP4	TMPRSS4
Description		RAS guanyl releasing protein 4	transmembrane serine protease 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Secretory Granule
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding GTPase Regulator Activity Metal Ion Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Positive Regulation Of Natural Killer Cell Mediated Immunity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Myeloid Cell Differentiation Cell Differentiation Antibacterial Innate Immune Response	Proteolysis Response To Wounding Regulation Of Gene Expression Protein Processing Negative Regulation Of Growth Rate Positive Regulation Of Viral Entry Into Host Cell
Pathways		FCERI mediated NF-kB activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Monocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		6 interacting genes: BNIP2 DYNLL1 HRAS RAP1A SEC22A TMPRSS4	14 interacting genes: BNIP3L CLEC7A CLRN1 ERVFRD-1 FAM209A FNDC9 GPX8 KASH5 LMNA RASGRP4 SIGLEC12 SUSD3 SYNE4 TMEM79
Entrez ID		115727	56649
HPRD ID		09540	05952
Ensembl ID		ENSG00000171777	ENSG00000137648
Uniprot IDs		Q8TDF6	A0AAQ5BHV4 B7Z458 B7Z8X1 B7Z900 E7ESG9 Q9NRS4
PDB IDs		6AXG
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade GDP Binding G Protein Activity Negative Regulation Of Growth Rate Regulation Of Cellular Localization GTPase Complex Response To Antineoplastic Agent Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Secretory Granule Regulation Of MAPK Cascade Phospholipase C Activator Activity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Perinuclear Region Of Cytoplasm Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Localization To Membrane Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Growth Rate Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Apoptotic Process Oncogene-induced Cell Senescence Cell Development Guanyl-nucleotide Exchange Factor Complex Cell Death Programmed Cell Death Regulation Of Protein Localization Nitric-oxide Synthase Regulator Activity Positive Regulation Of Intracellular Signal Transduction Spindle Pole Centrosome Response To Oxygen-glucose Deprivation GTPase Activity Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Positive Regulation Of Ruffle Assembly Small GTPase-mediated Signal Transduction T-helper 1 Type Immune Response Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Forskolin Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Nerve Growth Factor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	Nuclear Envelope Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex
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