NRXN3 and NLGN3

Number of citations of the paper that reports this interaction (PMID 8576240)
94

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NRXN3	NLGN3
Gene Name		neurexin 3	neuroligin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Space Integral Component Of Plasma Membrane Cell Surface Cell Junction Endocytic Vesicle Synapse Excitatory Synapse
	Molecular Function	Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Receptor Activity Protein Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding Carboxylic Ester Hydrolase Activity
	Biological Process	Angiogenesis Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Adult Behavior Social Behavior Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Synapse Maturation	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Synapse Assembly Learning Metabolic Process Visual Learning Adult Behavior Social Behavior Axon Extension Oligodendrocyte Differentiation Regulation Of Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Terminal Button Organization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728) Body mass index ( 20935630) Obesity ( 23563607 21552555) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist circumference ( 19557197)
Protein-Protein Interactions		5 interactors: CASK MLLT4 NLGN1 NLGN2 NLGN3	8 interactors: DLG2 DLG3 DLG4 MEOX2 NRXN1 NRXN2 NRXN3 PRDX2
Entrez ID		9369	54413
HPRD ID		08989	02275
Ensembl ID			ENSG00000196338
Uniprot IDs		Q9HDB5 Q9Y4C0	D3DVV1 Q4G160 Q9NZ94
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Respiratory Gaseous Exchange By Neurological System Process Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Membrane Biogenesis Postsynaptic Membrane Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Terminal Button Organization Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Cell Adhesion Synapse Assembly Regulation Of Ion Transmembrane Transport Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Postsynaptic Density Protein 95 Clustering Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ion Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Synapse Organization Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Cell-cell Signaling Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, GABAergic Membrane Hyperpolarization Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Development Positive Regulation Of Ion Transmembrane Transport Single Organismal Cell-cell Adhesion Synaptic Transmission Regulation Of Dendrite Development Cellular Component Assembly Cytoskeletal Matrix Organization At Active Zone	Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Social Behavior Receptor Clustering Synapse Assembly Synaptic Transmission Neuron Cell-cell Adhesion Protein Localization To Membrane Postsynaptic Membrane Organization Learning Cell-cell Signaling Neuroligin Clustering Synapse Organization Gephyrin Clustering Nucleotide Phosphorylation Vocal Learning Regulation Of Grooming Behavior Learning Or Memory Postsynaptic Membrane Assembly Cognition Postsynaptic Density Protein 95 Clustering Membrane Organization Auditory Behavior Neurotransmitter Secretion Axon Guidance Positive Regulation Of Synapse Maturation Single-organism Behavior Regulation Of Neurotransmitter Levels Regulation Of Synapse Maturation Secretion By Cell Neurological System Process Mechanosensory Behavior Axonogenesis Response To Auditory Stimulus Neurotransmitter Transport Adult Behavior Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Nervous System Development Membrane Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Behavior Cellular Localization Chemotaxis Cellular Protein Localization Membrane Biogenesis Secretion Neuron Projection Morphogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	88mm alcohol chip chromosomes cpg cyp4f13 defect deficit elavl2 epityper fasd hist1h3d igf2r imprinted imprinting islands landscape medip methylation neurofacial neurulation olfaction remarkably retardation sequenom sim1 sox21 tightly tube
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	88mm alcohol chip chromosomes cpg cyp4f13 defect deficit elavl2 epityper fasd hist1h3d igf2r imprinted imprinting islands landscape medip methylation neurofacial neurulation olfaction remarkably retardation sequenom sim1 sox21 tightly tube
Tagcloud (Intersection) ?