NRXN3

Description		neurexin 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Cell Projection Synapse Trans-synaptic Protein Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Angiogenesis Cell Adhesion Neuron Cell-cell Adhesion Signal Transduction Nervous System Development Axon Guidance Learning Adult Behavior Social Behavior Vocalization Behavior
Pathways		Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Adiponectin levels ( 33562295) Adult body size ( 32376654) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 28892062 28552196 28448500 26865924 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Bone mineral density (hip) ( 30172743) Chronotype ( 30696823) Coronary artery aneurysm in Kawasaki disease ( 27171184) Daytime nap ( 33568662) Depression x maternal smoking during pregnancy interaction ( 34118634) Electrodermal activity ( 25387706) Figural/spatial cognitive ability ( 31620175) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 25673412) JT interval (sulfonylurea treatment interaction) ( 27958378) Medial orbital frontal cortex volume ( 31530798) Normal facial asymmetry (angle of deformation score) ( 30631343) Obesity ( 21552555 23563607) Objective response to lithium treatment in bipolar disorder ( 26503763) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Postherpetic neuralgia ( 33685280) Proliferative diabetic retinopathy in type 2 diabetes ( 29739359) Response to antidepressants (symptom improvement) ( 29160301) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Smoking initiation ( 33082346) Tea consumption ( 31046077) TPE interval (recovery after exercise) ( 32386560) Type 2 diabetes ( 30054458 28566273 30297969) Underweight status ( 25133637) Urinary sodium excretion ( 31409800) Waist circumference ( 19557197 25673412) Waist-hip ratio ( 25673412) Walking pace ( 33128006) Weight ( 28552196)
Interacting Genes		8 interacting genes: AFDN CASK DNAJC5 HTR6 NLGN1 NLGN2 NLGN3 PAX4
Entrez ID		9369
HPRD ID		08989
Ensembl ID		ENSG00000021645
Uniprot IDs		A0A0A0MR89 A0A0U1RQC5 Q9HDB5 Q9Y4C0
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurexin Family Protein Binding Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Neuron To Neuron Synapse Presynaptic Membrane Organization Presynapse Assembly Neuron Cell-cell Adhesion Cell Adhesion Molecule Binding Presynapse Organization Excitatory Synapse Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Symmetric, GABA-ergic, Inhibitory Synapse Asymmetric, Glutamatergic, Excitatory Synapse Modulation Of Excitatory Postsynaptic Potential Terminal Button Organization Membrane Assembly Positive Regulation Of Synapse Assembly Postsynaptic Density Protein 95 Clustering Cell Junction Assembly Regulation Of Synaptic Transmission, Glutamatergic Synapse Assembly Regulation Of Respiratory Gaseous Exchange By Nervous System Process Positive Regulation Of Cell Junction Assembly Neurotransmitter-gated Ion Channel Clustering Cell Adhesion Regulation Of Nervous System Process Regulation Of Respiratory System Process Synapse Positive Regulation Of Synaptic Transmission, GABAergic Cell Junction Organization Positive Regulation Of Synaptic Transmission Cell-cell Adhesion Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Assembly Regulation Of Respiratory Gaseous Exchange Postsynaptic Specialization Membrane Cell-cell Signaling Regulation Of Synaptic Transmission, GABAergic Signaling Cell Communication Presynapse Postsynaptic Membrane Positive Regulation Of Dendritic Spine Development Synapse Organization Regulation Of Cell Junction Assembly Positive Regulation Of Nervous System Development Regulation Of Synaptic Vesicle Exocytosis Receptor Clustering
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