NPHS1 and NPHS2

Number of citations of the paper that reports this interaction (PubMedID 11733557)
43

Data Source:
HPRD (in vitro, in vivo)

		NPHS1	NPHS2
Description		NPHS1 adhesion molecule, nephrin	NPHS2 stomatin family member, podocin
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Slit Diaphragm Cell Projection Extracellular Exosome Cell Periphery	Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Membrane Protein-containing Complex Slit Diaphragm Membrane Raft Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Myosin Binding Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	MAPK Cascade Cell Adhesion JNK Cascade Muscle Organ Development Skeletal Muscle Tissue Development Myoblast Fusion Gene Expression Positive Regulation Of Actin Filament Polymerization Glomerular Basement Membrane Development Protein Localization To Synapse Slit Diaphragm Assembly Podocyte Development Cell-cell Adhesion	Glomerular Filtration Gene Expression Actin Cytoskeleton Organization Renal System Development Metanephric Podocyte Development
Pathways		Nephrin family interactions Nephrin family interactions	Nephrin family interactions
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS
Interacting Genes		11 interacting genes: CASK CD2AP FYN IQGAP1 KIRREL1 LYN NCK1 NCK2 NPHS2 SRC YES1	7 interacting genes: CD2AP FOXC1 FOXC2 KIRREL1 KIRREL3 LMX1B NPHS1
Entrez ID		4868	7827
HPRD ID		04094	05303
Ensembl ID		ENSG00000161270	ENSG00000116218
Uniprot IDs		O60500	Q9NP85
PDB IDs		4ZRT
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Cell-cell Junction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Actin Filament Ephrin Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Cell Migration Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Complex Assembly Slit Diaphragm T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Cell Motility Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Signaling Receptor Binding Immune Response-regulating Signaling Pathway Scaffold Protein Binding Activation Of Immune Response Response To Transforming Growth Factor Beta Regulation Of Cell Adhesion Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cellular Response To Lectin Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Periphery Actin Filament Organization Positive Regulation Of Immune System Process Response To Growth Factor Protein Tyrosine Kinase Activity Regulation Of Cell Activation Transmembrane Transporter Binding Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress	Apoptotic Process Involved In Outflow Tract Morphogenesis Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Cell-cell Junction Apoptotic Process Involved In Heart Morphogenesis Glomerular Epithelium Development Paraxial Mesoderm Formation Renal Protein Absorption Slit Diaphragm Cell Adhesion Molecule Binding Lymph Vessel Development Endothelium Development Podocyte Differentiation Cell Junction Organization Cell-cell Adhesion Kidney Development Embryonic Heart Tube Development Apoptotic Process Involved In Morphogenesis Cell-cell Junction Organization Myosin Binding Neural Crest Cell Development Cardiac Muscle Cell Proliferation Cell Differentiation Involved In Kidney Development Apoptotic Process Involved In Development Stem Cell Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Epithelium Development Extracellular Matrix Organization Tissue Development Extracellular Structure Organization Ureteric Bud Development Dendritic Shaft Blood Vessel Remodeling Regionalization Renal Absorption Cellular Developmental Process Muscle Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Mesoderm Formation Somitogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Actin Filament Polymerization Segmentation Cell Adhesion Cell Development Heart Morphogenesis Cardiac Muscle Tissue Morphogenesis Formation Of Primary Germ Layer Regulation Of Actin Cytoskeleton Organization
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