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NPHS1 and IQGAP1
Number of citations of the paper that reports this interaction (PubMedID
25652011
)
34
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
NPHS1
IQGAP1
Description
NPHS1 adhesion molecule, nephrin
IQ motif containing GTPase activating protein 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Membrane
Slit Diaphragm
Cell Projection
Extracellular Exosome
Cell Periphery
Ruffle
Nucleus
Cytoplasm
Cytosol
Microtubule
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Actin Cytoskeleton
Microtubule Cytoskeleton
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Axon
Growth Cone
Midbody
Secretory Granule Membrane
Cortical Actin Cytoskeleton
Cell Leading Edge
Slit Diaphragm
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Extracellular Exosome
Plasma Membrane Bounded Cell Projection
Ribonucleoprotein Complex
Molecular Function
Protein Binding
Myosin Binding
Cell Adhesion Molecule Binding
MAP-kinase Scaffold Activity
GTPase Inhibitor Activity
GTPase Activator Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Small GTPase Binding
Protein Serine/threonine Kinase Activator Activity
S100 Protein Binding
Cadherin Binding
Actin Filament Binding
Molecular Adaptor Activity
Biological Process
MAPK Cascade
Cell Adhesion
JNK Cascade
Muscle Organ Development
Skeletal Muscle Tissue Development
Myoblast Fusion
Gene Expression
Positive Regulation Of Actin Filament Polymerization
Glomerular Basement Membrane Development
Protein Localization To Synapse
Slit Diaphragm Assembly
Podocyte Development
Cell-cell Adhesion
MAPK Cascade
Regulation Of Cytokine Production
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Mitotic Cell Cycle
Fibroblast Growth Factor Receptor Signaling Pathway
Fibroblast Migration
Cell Migration
Negative Regulation Of Dephosphorylation
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of MAPK Cascade
Cellular Response To Fibroblast Growth Factor Stimulus
Platelet-derived Growth Factor Receptor Signaling Pathway
Caveola Assembly
Cellular Response To Calcium Ion
Cellular Response To Epidermal Growth Factor Stimulus
Podocyte Development
Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization
Neuron Projection Extension
Pathways
Nephrin family interactions
Nephrin family interactions
Nephrin family interactions
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
RHO GTPases activate IQGAPs
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
RHOA GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOU GTPase cycle
RHOV GTPase cycle
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Artenimol
Diseases
Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
31361310
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
32888494
)
Chronic postoperative pain (
31903573
)
Glaucoma (primary open-angle) (
33627673
)
Heel bone mineral density (
30598549
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Male-pattern baldness (
28196072
)
Multiple sclerosis (
24076602
)
Neutrophil percentage of white cells (
32888494
)
Red cell distribution width (
32888494
)
Rheumatoid arthritis (
32868391
)
White blood cell count (basophil) (
27863252
)
Interacting Genes
11 interacting genes:
CASK
CD2AP
FYN
IQGAP1
KIRREL1
LYN
NCK1
NCK2
NPHS2
SRC
YES1
45 interacting genes:
ACTA1
AIMP1
AKAP5
APC
CALM1
CDC42
CDH1
CDK1
CDK2
CEBPA
CLIC5
CLIP1
CREBBP
CTNNB1
CYBB
DSCAM
DUX4
EGFR
EZR
GRIA4
ILF2
KDR
LBX1
LCOR
MAPK1
MEI4
MEN1
MEOX2
MYL1
NPHS1
NRIP1
NUMB
OTX2
PDLIM7
PKNOX2
PRKACA
PTPRM
RAC1
S100B
STAU1
SUMO2
TEPSIN
TSG101
UBE2I
VASP
Entrez ID
4868
8826
HPRD ID
04094
04541
Ensembl ID
ENSG00000161270
ENSG00000140575
Uniprot IDs
O60500
A0A0J9YXZ5
P46940
PDB IDs
4ZRT
1X0H
2RR8
3FAY
3I6X
5L0O
Enriched GO Terms of Interacting Partners
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Ephrin Receptor Signaling Pathway
Cell-cell Junction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Platelet-derived Growth Factor Stimulus
Enzyme-linked Receptor Protein Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Response To Platelet-derived Growth Factor
Actin Filament
Ephrin Receptor Binding
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Immune Response-activating Cell Surface Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Cell Migration
Positive Regulation Of Leukocyte Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signal Complex Assembly
Slit Diaphragm
T Cell Costimulation
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Cell Motility
Immune Response-activating Signaling Pathway
Fc Receptor Signaling Pathway
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Signaling Receptor Binding
Immune Response-regulating Signaling Pathway
Scaffold Protein Binding
Activation Of Immune Response
Response To Transforming Growth Factor Beta
Regulation Of Cell Adhesion
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Cellular Response To Lectin
Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Cell Periphery
Actin Filament Organization
Positive Regulation Of Immune System Process
Response To Growth Factor
Protein Tyrosine Kinase Activity
Regulation Of Cell Activation
Transmembrane Transporter Binding
Positive Regulation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress
Intracellular Signaling Cassette
Cadherin Binding
Focal Adhesion
Positive Regulation Of Protein Localization
Developmental Process
Lamellipodium
Cell-cell Junction Organization
Positive Regulation Of Cellular Component Organization
Modulation Of Chemical Synaptic Transmission
Positive Regulation Of Organelle Organization
Cellular Developmental Process
Centrosome
Intracellular Signal Transduction
Glutamatergic Synapse
Cell Development
Neuron Fate Determination
Cell Projection
Cytoskeleton
Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Regulation Of Protein Localization
Cell Junction Organization
Positive Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Protein Catabolic Process
Regulation Of Transcription By RNA Polymerase II
Cell Periphery
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Organelle Organization
Regulation Of Cellular Localization
Actin Cytoskeleton
Adherens Junction
Cytoplasm
Adherens Junction Organization
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Phosphorylation
Regulation Of Cell Cycle
Regulation Of RNA Biosynthetic Process
Regulation Of Locomotion
Regulation Of Synaptic Plasticity
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Developmental Process
Cytosol
Cyclin-dependent Protein Kinase Activity
Regulation Of Protein Metabolic Process
Positive Regulation Of Locomotion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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