MKNK1 and HGS

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MKNK1	HGS
Gene Name		MAP kinase interacting serine/threonine kinase 1	hepatocyte growth factor-regulated tyrosine kinase substrate
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Regulation Of Translational Initiation Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Response To Salt Stress Peptidyl-serine Phosphorylation Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways		Signaling by FGFR in disease Spry regulation of FGF signaling Signaling by FGFR Negative regulation of FGFR signaling	Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Eye color traits ( 20463881)
Protein-Protein Interactions		25 interactors: APP ATXN3 CREBBP DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1	138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302
Entrez ID		8569	9146
HPRD ID		09468	05085
Ensembl ID		ENSG00000079277	ENSG00000185359
Uniprot IDs		A8K341 Q9BUB5	O14964
PDB IDs		2HW6 2Y9Q	2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Signaling Cellular Response To Stimulus Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Heat Enzyme Linked Receptor Protein Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Stimulus Response To Cytokine Defense Response Regulation Of Cellular Response To Heat Viral Process Response To Abiotic Stimulus Innate Immune Response Signal Transduction Cellular Response To Cytokine Stimulus Toll-like Receptor Signaling Pathway Response To Stress Response To Heat Peptidyl-serine Phosphorylation Regulation Of Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Pattern Recognition Receptor Signaling Pathway Immune Response Positive Regulation Of Cellular Metabolic Process Innate Immune Response-activating Signal Transduction Cellular Protein Metabolic Process Regulation Of Translation Immune Response-regulating Signaling Pathway Immune System Process Activation Of Innate Immune Response Cell Cycle Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cell Death Death TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Gene Expression Cellular Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Gene Expression	Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance
Tagcloud ?		4ebp1 90kda alphas1 alphas2 casein caseins cows dairy eif4e eif4g export igfbp3 igfbp5 lactating mtorc1 nonpregnant nucleocytoplasmic p70 p85 parenchymal patsearch rps6ka1 s6k ser209 ser2448 ser65 thr197202 thre389 thre412	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Difference) ?		4ebp1 90kda alphas1 alphas2 casein caseins cows dairy eif4e eif4g export igfbp3 igfbp5 lactating mtorc1 nonpregnant nucleocytoplasmic p70 p85 parenchymal patsearch rps6ka1 s6k ser209 ser2448 ser65 thr197202 thre389 thre412	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Intersection) ?