MKNK1 and PLA2G4A

Number of citations of the paper that reports this interaction (PMID 10978317)
43

Data Source:
HPRD (in vitro, in vivo)

		MKNK1	PLA2G4A
Gene Name		MAP kinase interacting serine/threonine kinase 1	phospholipase A2, group IVA (cytosolic, calcium-dependent)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Regulation Of Translational Initiation Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Response To Salt Stress Peptidyl-serine Phosphorylation Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Blood Coagulation Phospholipid Catabolic Process Arachidonic Acid Metabolic Process Platelet Activation Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Regulation Of Cell Proliferation Small Molecule Metabolic Process Icosanoid Biosynthetic Process Glycerophospholipid Biosynthetic Process Arachidonic Acid Secretion Cellular Response To Antibiotic
Pathways		Signaling by FGFR in disease Spry regulation of FGF signaling Signaling by FGFR Negative regulation of FGFR signaling	phospho-PLA2 pathway Ca-dependent events Signaling by GPCR Acyl chain remodeling of CL ADP signalling through P2Y purinoceptor 1 Hydrolysis of LPC Acyl chain remodelling of PE Metabolism of lipids and lipoproteins Signal amplification Arachidonic acid metabolism Phospholipid metabolism Acyl chain remodelling of PC Synthesis of PA PLC beta mediated events Opioid Signalling Glycerophospholipid biosynthesis G-protein mediated events Acyl chain remodelling of PS Acyl chain remodelling of PG Platelet homeostasis Acyl chain remodelling of PI Platelet sensitization by LDL Platelet activation, signaling and aggregation
Drugs			Fluticasone Propionate Quinacrine Niflumic Acid
Diseases
GWAS			Epilepsy (generalized) ( 22949513) Knee osteoarthritis ( 18471798)
Protein-Protein Interactions		25 interactors: APP ATXN3 CREBBP DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1	18 interactors: C17orf59 CAP1 CASP1 CASP3 CASP4 EHD1 JAK1 KAT5 MAPK14 MAPKAPK5 MKNK1 PLA2G5 RELA RPS6KA5 SHBG UBXN1 VIM XAGE1E
Entrez ID		8569	5321
HPRD ID		09468	08986
Ensembl ID		ENSG00000079277	ENSG00000116711
Uniprot IDs		A8K341 Q9BUB5	E7EU42 P47712
PDB IDs		2HW6 2Y9Q	1BCI 1CJY 1RLW
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Signaling Cellular Response To Stimulus Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Heat Enzyme Linked Receptor Protein Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Stimulus Response To Cytokine Defense Response Regulation Of Cellular Response To Heat Viral Process Response To Abiotic Stimulus Innate Immune Response Signal Transduction Cellular Response To Cytokine Stimulus Toll-like Receptor Signaling Pathway Response To Stress Response To Heat Peptidyl-serine Phosphorylation Regulation Of Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Pattern Recognition Receptor Signaling Pathway Immune Response Positive Regulation Of Cellular Metabolic Process Innate Immune Response-activating Signal Transduction Cellular Protein Metabolic Process Regulation Of Translation Immune Response-regulating Signaling Pathway Immune System Process Activation Of Innate Immune Response Cell Cycle Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cell Death Death TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Phosphorylation MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Gene Expression Cellular Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Gene Expression	Cellular Response To Organic Substance Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Execution Phase Of Apoptosis Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stress Apoptotic Process Response To Growth Factor Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Programmed Cell Death Activation Of Innate Immune Response Cell Death Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Innate Immune Response Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cytokine Production Stress-induced Premature Senescence Positive Regulation Of Myoblast Fusion Response To Muramyl Dipeptide Response To Abiotic Stimulus Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Peptidyl-serine Phosphorylation Response To Tumor Necrosis Factor Signal Transduction
Tagcloud ?		4ebp1 90kda alphas1 alphas2 casein caseins cows dairy eif4e eif4g export igfbp3 igfbp5 lactating mtorc1 nonpregnant nucleocytoplasmic p70 p85 parenchymal patsearch rps6ka1 s6k ser209 ser2448 ser65 thr197202 thre389 thre412	11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?		4ebp1 90kda alphas1 alphas2 casein caseins cows dairy eif4e eif4g export igfbp3 igfbp5 lactating mtorc1 nonpregnant nucleocytoplasmic p70 p85 parenchymal patsearch rps6ka1 s6k ser209 ser2448 ser65 thr197202 thre389 thre412	11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Intersection) ?