MKNK1 and RCN3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MKNK1	RCN3
Description		MAPK interacting serine/threonine kinase 1	reticulocalbin 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Translation Protein Phosphorylation Intracellular Signal Transduction	Protein Secretion Positive Regulation Of Peptidase Activity Protein Transport Collagen Biosynthetic Process ERAD Pathway Surfactant Homeostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phospholipid Homeostasis Lung Epithelium Development
Pathways		Spry regulation of FGF signaling
Drugs		Fostamatinib
Diseases
GWAS		Schizophrenia ( 26198764) Triglyceride levels ( 31170924)	Apolipoprotein A1 levels ( 32203549) Fructosamine levels ( 29844224 34753797) Height ( 31562340) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Mean spheric corpuscular volume ( 32888494) Schizophrenia ( 25056061) Total glycated albumin levels ( 29844224)
Interacting Genes		26 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1	15 interacting genes: DNAAF19 EZH2 HID1 KLHL42 MBD3 MKNK1 MYO15B NAA10 PACRGL PCSK6 PDE4B PRUNE2 STAT6 SUFU ZNF417
Entrez ID		8569	57333
HPRD ID		09468	17962
Ensembl ID		ENSG00000079277	ENSG00000142552
Uniprot IDs		A0A499FJN1 A0A499FJS1 A8K341 Q9BUB5	Q96D15
PDB IDs		2HW6 2Y9Q 5WVD
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Catabolic Process Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Cytosol Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Lung Morphogenesis Intracellular Signal Transduction Cellular Response To Nutrient Levels Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Regulation Of Gene Expression Negative Regulation Of Autophagy Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Translation Initiation Factor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Signal Transduction Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling MAP Kinase Activity Regulation Of Translation Cytoplasm Regulation Of Defense Response Nucleus Intracellular Signaling Cassette Translation Factor Activity, RNA Binding Positive Regulation Of Defense Response Stress-activated MAPK Cascade Interleukin-34-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Translational Initiation Cell Death Stress-activated Protein Kinase Signaling Cascade Response To Growth Factor Regulation Of Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Developmental Process Cytoplasmic Stress Granule Thyroid Gland Development	Determination Of Bilateral Symmetry Determination Of Left/right Symmetry
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