MKNK1

Name	MAPK interacting serine/threonine kinase 1
Structure
Novel Interactors	1 novel interactors: PABPC4
Interactors	26 interactors: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Translation Protein Phosphorylation Intracellular Signal Transduction
Pathways	Spry regulation of FGF signaling
Drugs	Fostamatinib
GWAS	Schizophrenia ( 26198764 ) Triglyceride levels ( 31170924 )
Entrez ID	8569
HPRD ID	09468
Ensembl ID	ENSG00000079277
Uniprot IDs	A0A499FJN1 A0A499FJS1 A8K341 Q9BUB5
PDB IDs	2HW6 2Y9Q 5WVD
GO Terms Enriched among Interactors ?	Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Catabolic Process Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Post-transcriptional Regulation Of Gene Expression Cytosol Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Lung Morphogenesis Intracellular Signal Transduction Cellular Response To Nutrient Levels Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Regulation Of Gene Expression Negative Regulation Of Autophagy Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Translation Initiation Factor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Signal Transduction Regulation Of Proteolysis Regulation Of Cell Communication Regulation Of Signaling MAP Kinase Activity Regulation Of Translation Cytoplasm Regulation Of Defense Response Nucleus Intracellular Signaling Cassette Translation Factor Activity, RNA Binding Positive Regulation Of Defense Response Stress-activated MAPK Cascade Interleukin-34-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Translational Initiation Cell Death Stress-activated Protein Kinase Signaling Cascade Response To Growth Factor Regulation Of Immune Response Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Stress Developmental Process Cytoplasmic Stress Granule Thyroid Gland Development