Wiki-Pi
About
Search
People
Updates
Search
MKNK1 and PAK2
Number of citations of the paper that reports this interaction (PubMedID
25241761
)
0
Data Source:
BioGRID
(imaging technique)
HPRD
(in vitro, in vivo)
MKNK1
PAK2
Description
MAPK interacting serine/threonine kinase 1
p21 (RAC1) activated kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Postsynaptic Density
Membrane
Nuclear Speck
Secretory Granule
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium/calmodulin-dependent Protein Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Calcium-dependent Protein Serine/threonine Kinase Activity
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
Catalytic Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Small GTPase Binding
Identical Protein Binding
Cadherin Binding
Protein Serine Kinase Activity
Biological Process
Regulation Of Translation
Protein Phosphorylation
Intracellular Signal Transduction
Stimulatory C-type Lectin Receptor Signaling Pathway
Cardiac Muscle Hypertrophy
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Starvation
Cell Migration
Adherens Junction Assembly
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Protein Maturation
Dendritic Spine Development
Bicellular Tight Junction Assembly
Cellular Response To Transforming Growth Factor Beta Stimulus
Execution Phase Of Apoptosis
Regulation Of Actin Filament Organization
Protein Localization To Cell-cell Junction
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Spry regulation of FGF signaling
Nef and signal transduction
Generation of second messenger molecules
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Stimulation of the cell death response by PAK-2p34
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Drugs
Fostamatinib
Fostamatinib
Diseases
GWAS
Schizophrenia (
26198764
)
Triglyceride levels (
31170924
)
Asthma (
31959851
)
Atrial fibrillation (
29892015
)
Eosinophil count (
32888494
27863252
)
Glucose homeostasis traits (
25524916
)
Lymphocyte count (
27863252
32888494
)
Malaria (
31844061
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
27863252
32888494
)
Neutrophil count (
32888494
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Total ventricular volume (Alzheimer's disease interaction) (
21116278
)
White blood cell count (
27863252
32888494
)
Interacting Genes
26 interacting genes:
APP
ATXN3
CREBBP
CREM
DDAH2
DNAJC7
EIF4E
EIF4G1
EIF4G2
EIF4G3
FANCA
HGS
HIPK2
HSP90AB1
MAPK1
MAPK14
MAPK3
MBP
PAK2
PHAX
PLA2G4A
PRKDC
RCN3
SPRY2
TNIP2
UBE2D1
54 interacting genes:
ABI1
ABI2
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
CEBPA
DOCK2
DSCR9
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
H4C6
HCK
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NPHP1
OGT
PACSIN3
PPM1A
RAC1
RAF1
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
Entrez ID
8569
5062
HPRD ID
09468
05428
Ensembl ID
ENSG00000079277
ENSG00000180370
Uniprot IDs
A0A499FJN1
A0A499FJS1
A8K341
Q9BUB5
A8K5M4
Q13177
PDB IDs
2HW6
2Y9Q
5WVD
3PCS
Enriched GO Terms of Interacting Partners
?
Regulation Of Protein Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Catabolic Process
Eukaryotic Translation Initiation Factor 4F Complex
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Cytosol
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Lung Morphogenesis
Intracellular Signal Transduction
Cellular Response To Nutrient Levels
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Nutrient Levels
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Regulation Of Macromolecule Biosynthetic Process
Protein Metabolic Process
Translation Initiation Factor Activity
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cellular Response To Stress
Regulation Of Signal Transduction
Regulation Of Proteolysis
Regulation Of Cell Communication
Regulation Of Signaling
MAP Kinase Activity
Regulation Of Translation
Cytoplasm
Regulation Of Defense Response
Nucleus
Intracellular Signaling Cassette
Translation Factor Activity, RNA Binding
Positive Regulation Of Defense Response
Stress-activated MAPK Cascade
Interleukin-34-mediated Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Translational Initiation
Cell Death
Stress-activated Protein Kinase Signaling Cascade
Response To Growth Factor
Regulation Of Immune Response
Regulation Of Cellular Response To Growth Factor Stimulus
Cellular Response To Stress
Developmental Process
Cytoplasmic Stress Granule
Thyroid Gland Development
Regulation Of Cellular Component Organization
Cytosol
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Intracellular Signal Transduction
Regulation Of Vesicle-mediated Transport
Cytoskeleton Organization
Positive Regulation Of Cellular Component Organization
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Cytoplasm
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Enzyme-linked Receptor Protein Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of MAPK Cascade
Focal Adhesion
Protein Phosphorylation
Ephrin Receptor Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Organelle Organization
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Fc Receptor Signaling Pathway
Phosphorylation
Positive Regulation Of Cytoskeleton Organization
Signal Transduction
Anchoring Junction
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Organelle Organization
Cell Surface Receptor Signaling Pathway
Regulation Of Protein-containing Complex Assembly
Immune Response-activating Signaling Pathway
Actin Cytoskeleton Organization
Non-membrane Spanning Protein Tyrosine Kinase Activity
Endocytosis
Regulation Of Cell Activation
Regulation Of Transport
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Regulation Of Supramolecular Fiber Organization
Regulation Of Endocytosis
Regulation Of T Cell Activation
Ephrin Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Supramolecular Fiber Organization
Actin Filament-based Process
Protein Kinase Activity
Lamellipodium
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?