TCAP and HSPG2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		TCAP	HSPG2
Description		titin-cap	heparan sulfate proteoglycan 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Sarcomere Z Disc I Band Titin-telethonin Complex	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Neuron Projection Lysosomal Lumen Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	Protein Binding Structural Constituent Of Muscle Protein-macromolecule Adaptor Activity Titin Binding BMP Binding Transmembrane Transporter Binding FATZ Binding Molecular Adaptor Activity Titin Z Domain Binding	Amyloid-beta Binding Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Collagen V Binding
	Biological Process	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Animal Organ Morphogenesis Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Anatomical Structure Formation Involved In Morphogenesis Tissue Morphogenesis Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly	Angiogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Negative Regulation Of Cell Adhesion Smoothened Signaling Pathway Brain Development Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Angiogenesis Cell Differentiation Animal Organ Regeneration Negative Regulation Of Neuron Apoptotic Process Circulatory System Development Negative Regulation Of Amyloid Fibril Formation
Pathways		Striated Muscle Contraction	Degradation of the extracellular matrix Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Palifermin
Diseases		Limb-girdle muscular dystrophy (LGMD)	Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Alcohol consumption ( 31358974) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799)	Atrial fibrillation ( 30061737) Cerebral microbleeds (lobar) ( 32913026) Height ( 28552196) PR interval ( 32439900)
Interacting Genes		38 interacting genes: ACTMAP ADPGK ANKRD2 ASB6 ATXN1 BLZF1 CDCA4 CHORDC1 CRK ENO1 ENO3 FAM153B FAS FYN GSK3B HSPB2 HSPB3 HSPG2 IKZF3 KLHL41 KRTAP19-7 LAMTOR5 LHX4 MDM2 MSTN MYOZ1 MYOZ3 NUP133 PAX7 PDPK1 RELA SAPCD1 SIVA1 TRIM54 TRIM55 TRIM63 TTC19 TTN	33 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN HSP90AA1 ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1
Entrez ID		8557	3339
HPRD ID		05133	00804
Ensembl ID		ENSG00000173991	ENSG00000142798
Uniprot IDs		A2TDC0 O15273	P98160
PDB IDs		1YA5 2F8V	3SH4 3SH5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process M Band Telethonin Binding Actinin Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glycolytic Process Through Glucose-6-phosphate Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Glycolytic Process Through Fructose-6-phosphate Regulation Of Myoblast Proliferation Z Disc Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization Skeletal Muscle Atrophy Myofibril Assembly FATZ Binding Response To Hydrogen Peroxide Activation-induced Cell Death Of T Cells Diapedesis Cellular Response To Hormone Stimulus Skeletal Muscle Adaptation Striated Muscle Atrophy Extrinsic Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway Glycolytic Process Muscle Atrophy Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ADP Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Enzyme Binding Purine Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Intracellular Signal Transduction Muscle System Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Phospholipase Activator Activity Nucleoside Diphosphate Catabolic Process Muscle Structure Development Reelin-mediated Signaling Pathway Skeletal Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Hormone Response To Reactive Oxygen Species Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Pyruvate Metabolic Process	Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Extracellular Space Basement Membrane Heparin Binding Collagen Binding Positive Regulation Of Cell Migration Integrin Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Cell-matrix Adhesion Regulation Of Cell Motility Regulation Of Locomotion Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet Alpha Granule Lumen Regulation Of Endothelial Cell Proliferation Chemoattractant Activity Growth Factor Activity Peptidase Activator Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Integrin-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Positive Chemotaxis Positive Regulation Of Cell Communication Positive Regulation Of Epithelial Cell Proliferation Response To Wounding Positive Regulation Of Endothelial Cell Migration Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Animal Organ Development
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