TCAP and MSTN

Number of citations of the paper that reports this interaction (PMID 12209887)
14

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TCAP	MSTN
Gene Name		titin-cap	myostatin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Z Disc I Band	Extracellular Space Cytoplasm
	Molecular Function	Protein Binding Structural Constituent Of Muscle Protein Binding, Bridging Titin Binding BMP Binding Ion Channel Binding FATZ Binding Titin Z Domain Binding	Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding
	Biological Process	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Protein Complex Assembly Adult Heart Development Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Cardiac Muscle Fiber Development Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Response To Heat Response To Gravity Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of MAPK Cascade Response To Estrogen Response To Ethanol Positive Regulation Of Transcription, DNA-templated Cell Development Negative Regulation Of Skeletal Muscle Tissue Growth Response To Electrical Stimulus SMAD Protein Signal Transduction Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ANKRD2 ATXN1 FAS FYN MDM2 MSTN MYOZ1 MYOZ3 PDPK1 RELA SIVA1 TRIM55 TRIM63 TTN	6 interactors: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2
Entrez ID		8557	2660
HPRD ID		05133	03474
Ensembl ID			ENSG00000138379
Uniprot IDs		A2TDC0 O15273	O14793 Q53S46
PDB IDs		1YA5 2F8V
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Response To Hormone Cellular Response To Hormone Stimulus Response To Steroid Hormone Skeletal Muscle Atrophy Response To Mechanical Stimulus Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Striated Muscle Atrophy Activation-induced Cell Death Of T Cells Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Death Muscle Atrophy Cellular Response To Growth Factor Stimulus Muscle System Process Response To Growth Factor Skeletal Muscle Adaptation Fc Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Organic Substance Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Response To Stimulus T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Apoptotic Process Organ Development Cellular Response To Organic Cyclic Compound Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Signaling Response To Lipid Regulation Of Protein Metabolic Process Cellular Response To Lipid Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Negative Regulation Of Apoptotic Process Signaling Response To Glucocorticoid Negative Regulation Of Programmed Cell Death Cellular Response To Organonitrogen Compound Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Communication Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Inorganic Substance	Regulation Of Activin Receptor Signaling Pathway Muscle Fiber Development Palate Development Cell Differentiation Synaptic Growth At Neuromuscular Junction Regulation Of Protein Binding Striated Muscle Cell Development Sarcomerogenesis Collateral Sprouting In Absence Of Injury Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Muscle Cell Development System Development Collateral Sprouting Axon Midline Choice Point Recognition Myosin Filament Assembly Striated Muscle Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Multicellular Organismal Development Axon Choice Point Recognition Skeletal Muscle Thin Filament Assembly Lung Development Anterior/posterior Pattern Specification Respiratory Tube Development Regulation Of Binding Negative Regulation Of Endopeptidase Activity Positive Regulation Of Activin Receptor Signaling Pathway Anatomical Structure Development Negative Regulation Of Peptidase Activity Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Lymphatic Endothelial Cell Differentiation Respiratory System Development Neuron Remodeling Negative Regulation Of Activin Receptor Signaling Pathway Kidney Development Muscle Cell Differentiation Otic Vesicle Formation Renal System Development Lymphangiogenesis Organ Development Negative Regulation Of Proteolysis Otic Vesicle Morphogenesis Developmental Process Lymph Vessel Morphogenesis Negative Regulation Of Protein Processing Urogenital System Development Regulation Of Endopeptidase Activity
Tagcloud ?		allegedly catalysis conformationally coordinating crd dichotomy e147 inactivity invertebrate m34 mechanosensing murf1 murf2 myofibril myofibrillogenesis myofilament pseudokinase pseudokinases releases sarcomeric sterically stretch striated titin tk transfers translates trophicity unfolding	adenoviral adenovirus aforesaid backgrounds conversion decades ectopic electroporation eliminating facilitated fibroblasts fos lentiviral master muscle muscles myoblasts myod myogenesis myogenic myostatin myotubes negligible offers scarcity take transduced transducing wasting
Tagcloud (Difference) ?		allegedly catalysis conformationally coordinating crd dichotomy e147 inactivity invertebrate m34 mechanosensing murf1 murf2 myofibril myofibrillogenesis myofilament pseudokinase pseudokinases releases sarcomeric sterically stretch striated titin tk transfers translates trophicity unfolding	adenoviral adenovirus aforesaid backgrounds conversion decades ectopic electroporation eliminating facilitated fibroblasts fos lentiviral master muscle muscles myoblasts myod myogenesis myogenic myostatin myotubes negligible offers scarcity take transduced transducing wasting
Tagcloud (Intersection) ?