TCAP and ANKRD2

Number of citations of the paper that reports this interaction (PubMedID 15136035)
0

Data Source:
HPRD (in vivo, in vitro)

		TCAP	ANKRD2
Description		titin-cap	ankyrin repeat domain 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Sarcomere Z Disc I Band Titin-telethonin Complex	Euchromatin Nucleus Cytoplasm Cytosol PML Body I Band
	Molecular Function	Protein Binding Structural Constituent Of Muscle Protein-macromolecule Adaptor Activity Titin Binding BMP Binding Transmembrane Transporter Binding FATZ Binding Molecular Adaptor Activity Titin Z Domain Binding	Protein Binding Structural Constituent Of Muscle Protein Kinase B Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Animal Organ Morphogenesis Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Anatomical Structure Formation Involved In Morphogenesis Tissue Morphogenesis Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Muscle Contraction Muscle Organ Development Regulation Of Gene Expression Negative Regulation Of Myoblast Differentiation
Pathways		Striated Muscle Contraction
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD)
GWAS		Alcohol consumption ( 31358974) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799)
Interacting Genes		38 interacting genes: ACTMAP ADPGK ANKRD2 ASB6 ATXN1 BLZF1 CDCA4 CHORDC1 CRK ENO1 ENO3 FAM153B FAS FYN GSK3B HSPB2 HSPB3 HSPG2 IKZF3 KLHL41 KRTAP19-7 LAMTOR5 LHX4 MDM2 MSTN MYOZ1 MYOZ3 NUP133 PAX7 PDPK1 RELA SAPCD1 SIVA1 TRIM54 TRIM55 TRIM63 TTC19 TTN	11 interacting genes: FCMR HBP1 HOMEZ LDB3 MAPK6 PML TCAP TP53 TTN YBX1 ZBTB3
Entrez ID		8557	26287
HPRD ID		05133	12460
Ensembl ID		ENSG00000173991	ENSG00000165887
Uniprot IDs		A2TDC0 O15273	A0A0A0MRN9 Q5T457 Q9GZV1
PDB IDs		1YA5 2F8V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process M Band Telethonin Binding Actinin Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glycolytic Process Through Glucose-6-phosphate Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Glycolytic Process Through Fructose-6-phosphate Regulation Of Myoblast Proliferation Z Disc Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization Skeletal Muscle Atrophy Myofibril Assembly FATZ Binding Response To Hydrogen Peroxide Activation-induced Cell Death Of T Cells Diapedesis Cellular Response To Hormone Stimulus Skeletal Muscle Adaptation Striated Muscle Atrophy Extrinsic Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway Glycolytic Process Muscle Atrophy Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ADP Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Enzyme Binding Purine Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Intracellular Signal Transduction Muscle System Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Phospholipase Activator Activity Nucleoside Diphosphate Catabolic Process Muscle Structure Development Reelin-mediated Signaling Pathway Skeletal Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Hormone Response To Reactive Oxygen Species Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Pyruvate Metabolic Process	Titin-telethonin Complex Sarcomerogenesis Skeletal Muscle Myosin Thick Filament Assembly Myosin Filament Assembly Sarcomere Organization Skeletal Muscle Thin Filament Assembly Detection Of Muscle Stretch Muscle Alpha-actinin Binding Cardiac Myofibril Assembly Muscle Filament Sliding Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Telomere Maintenance Via Telomerase Z Disc Entrainment Of Circadian Clock By Photoperiod Cardiac Muscle Hypertrophy Response To Muscle Stretch I Band Photoperiodism Entrainment Of Circadian Clock Muscle Hypertrophy Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Myofibril Assembly Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Skeletal Muscle Contraction Negative Regulation Of Telomere Maintenance Actin-mediated Cell Contraction Cardiac Muscle Cell Development Regulation Of Telomere Maintenance Via Telomerase Structural Constituent Of Muscle Cardiac Muscle Contraction Cardiac Cell Development Detection Of Mechanical Stimulus Somitogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Senescence Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Segmentation Negative Regulation Of Translation In Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Heart Development Cardiac Muscle Tissue Morphogenesis High-affinity IgM Receptor Activity Actin Filament-based Movement Cellular Senescence
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