TCAP and ANKRD2

Number of citations of the paper that reports this interaction (PMID 15136035)
34

Data Source:
HPRD (in vivo, in vitro)

		TCAP	ANKRD2
Gene Name		titin-cap	ankyrin repeat domain 2 (stretch responsive muscle)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Z Disc I Band	Euchromatin Nucleus Cytosol PML Body Sarcomere I Band Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Structural Constituent Of Muscle Protein Binding, Bridging Titin Binding BMP Binding Ion Channel Binding FATZ Binding Titin Z Domain Binding	Structural Constituent Of Muscle Titin Binding Protein Kinase B Binding RNA Polymerase II Sequence-specific DNA Binding Transcription Factor Binding
	Biological Process	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Protein Complex Assembly Adult Heart Development Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Cardiac Muscle Fiber Development Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Muscle Organ Development Skeletal Muscle Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Negative Regulation Of Myoblast Differentiation
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ANKRD2 ATXN1 FAS FYN MDM2 MSTN MYOZ1 MYOZ3 PDPK1 RELA SIVA1 TRIM55 TRIM63 TTN	8 interactors: FAIM3 HBP1 PML TCAP TP53 TTN YBX1 ZBTB3
Entrez ID		8557	26287
HPRD ID		05133	12460
Ensembl ID			ENSG00000165887
Uniprot IDs		A2TDC0 O15273	Q9GZV1
PDB IDs		1YA5 2F8V
Enriched GO Terms of Interacting Partners?		Response To Abiotic Stimulus Response To Hormone Cellular Response To Hormone Stimulus Response To Steroid Hormone Skeletal Muscle Atrophy Response To Mechanical Stimulus Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Striated Muscle Atrophy Activation-induced Cell Death Of T Cells Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Death Muscle Atrophy Cellular Response To Growth Factor Stimulus Muscle System Process Response To Growth Factor Skeletal Muscle Adaptation Fc Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Organic Substance Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Response To Stimulus T Cell Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Apoptotic Process Organ Development Cellular Response To Organic Cyclic Compound Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Signaling Response To Lipid Regulation Of Protein Metabolic Process Cellular Response To Lipid Response To Organic Cyclic Compound Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Negative Regulation Of Apoptotic Process Signaling Response To Glucocorticoid Negative Regulation Of Programmed Cell Death Cellular Response To Organonitrogen Compound Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Communication Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Inorganic Substance	Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Detection Of Muscle Stretch Myosin Filament Assembly Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Cardiac Muscle Fiber Development Response To Muscle Stretch Cell Cycle Arrest Adult Heart Development Protein Import Positive Regulation Of Histone Deacetylation Cardiac Myofibril Assembly Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Protein Deacetylation Cardiac Muscle Hypertrophy Photoperiodism Entrainment Of Circadian Clock Muscle Hypertrophy Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Senescence Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Histone Deacetylation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Actin-mediated Cell Contraction Negative Regulation Of DNA Replication Detection Of Mechanical Stimulus Regulation Of Protein Deacetylation Muscle Fiber Development Response To Gamma Radiation Cardiac Muscle Contraction Sarcomere Organization DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cardiac Muscle Tissue Morphogenesis Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Actin Filament-based Movement Muscle Tissue Morphogenesis Regulation Of Tissue Remodeling Heart Contraction Protein Complex Assembly Cell Cycle Process Cardiac Muscle Cell Development Muscle Organ Morphogenesis Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint
Tagcloud ?		allegedly catalysis conformationally coordinating crd dichotomy e147 inactivity invertebrate m34 mechanosensing murf1 murf2 myofibril myofibrillogenesis myofilament pseudokinase pseudokinases releases sarcomeric sterically stretch striated titin tk transfers translates trophicity unfolding	a165v a171t actinin2 alternatively cardiomyopathy compaction competition cypher cytoskeletal differs dilated homologue indication lethality lim mechanosensing motif multiprotein myofibrillar myopathy nomenclature pdz sarcomeres spliced striated sumoylation zasp zaspopathy zm
Tagcloud (Difference) ?		allegedly catalysis conformationally coordinating crd dichotomy e147 inactivity invertebrate m34 murf1 murf2 myofibril myofibrillogenesis myofilament pseudokinase pseudokinases releases sarcomeric sterically stretch titin tk transfers translates trophicity unfolding	a165v a171t actinin2 alternatively cardiomyopathy compaction competition cypher cytoskeletal differs dilated homologue indication lethality lim motif multiprotein myofibrillar myopathy nomenclature pdz sarcomeres spliced sumoylation zasp zaspopathy zm
Tagcloud (Intersection) ?		mechanosensing striated