TCAP and ADPGK

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		TCAP	ADPGK
Description		titin-cap	ADP dependent glucokinase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Sarcomere Z Disc I Band Titin-telethonin Complex	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Structural Constituent Of Muscle Protein-macromolecule Adaptor Activity Titin Binding BMP Binding Transmembrane Transporter Binding FATZ Binding Molecular Adaptor Activity Titin Z Domain Binding	Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor ADP-specific Glucokinase Activity Metal Ion Binding
	Biological Process	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Animal Organ Morphogenesis Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Anatomical Structure Formation Involved In Morphogenesis Tissue Morphogenesis Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly	Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Glycolytic Process Through Glucose-6-phosphate
Pathways		Striated Muscle Contraction	Glycolysis
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD)
GWAS		Alcohol consumption ( 31358974) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799)	Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Hand grip strength ( 29691431) Triglyceride levels ( 28334899) Urate levels ( 23263486) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		38 interacting genes: ACTMAP ADPGK ANKRD2 ASB6 ATXN1 BLZF1 CDCA4 CHORDC1 CRK ENO1 ENO3 FAM153B FAS FYN GSK3B HSPB2 HSPB3 HSPG2 IKZF3 KLHL41 KRTAP19-7 LAMTOR5 LHX4 MDM2 MSTN MYOZ1 MYOZ3 NUP133 PAX7 PDPK1 RELA SAPCD1 SIVA1 TRIM54 TRIM55 TRIM63 TTC19 TTN	5 interacting genes: GDF9 OGT TADA3 TCAP UBQLN4
Entrez ID		8557	83440
HPRD ID		05133	12429
Ensembl ID		ENSG00000173991	ENSG00000159322
Uniprot IDs		A2TDC0 O15273	Q9BRR6
PDB IDs		1YA5 2F8V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process M Band Telethonin Binding Actinin Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glycolytic Process Through Glucose-6-phosphate Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Glycolytic Process Through Fructose-6-phosphate Regulation Of Myoblast Proliferation Z Disc Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization Skeletal Muscle Atrophy Myofibril Assembly FATZ Binding Response To Hydrogen Peroxide Activation-induced Cell Death Of T Cells Diapedesis Cellular Response To Hormone Stimulus Skeletal Muscle Adaptation Striated Muscle Atrophy Extrinsic Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway Glycolytic Process Muscle Atrophy Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ADP Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Enzyme Binding Purine Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Intracellular Signal Transduction Muscle System Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Phospholipase Activator Activity Nucleoside Diphosphate Catabolic Process Muscle Structure Development Reelin-mediated Signaling Pathway Skeletal Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Hormone Response To Reactive Oxygen Species Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Pyruvate Metabolic Process	Regulation Of Female Gonad Development Regulation Of Progesterone Secretion Oocyte Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Titin-telethonin Complex Titin Z Domain Binding Detection Of Muscle Stretch Otic Vesicle Formation Myosin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly FATZ Binding Sarcomerogenesis Skeletal Muscle Thin Filament Assembly Regulation Of DNA Repair Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Cytosolic Proteasome Complex Membraneless Organelle Assembly Regulation Of Transcription By Glucose Autophagy K48-linked Polyubiquitin Modification-dependent Protein Binding NSL Complex Cardiac Muscle Hypertrophy In Response To Stress Adult Heart Development Titin Binding ATAC Complex Cardiac Myofibril Assembly Muscle Filament Sliding Regulation Of Autophagosome Maturation Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis Actin-myosin Filament Sliding Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Transcription Factor TFTC Complex Acetylglucosaminyltransferase Activity
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