TCAP and FAM153B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCAP	FAM153B
Description		titin-cap	protein FAM153B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Sarcomere Z Disc I Band Titin-telethonin Complex
	Molecular Function	Protein Binding Structural Constituent Of Muscle Protein-macromolecule Adaptor Activity Titin Binding BMP Binding Transmembrane Transporter Binding FATZ Binding Molecular Adaptor Activity Titin Z Domain Binding	Protein Binding
	Biological Process	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Animal Organ Morphogenesis Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Anatomical Structure Formation Involved In Morphogenesis Tissue Morphogenesis Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly
Pathways		Striated Muscle Contraction
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD)
GWAS		Alcohol consumption ( 31358974) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799)
Interacting Genes		38 interacting genes: ACTMAP ADPGK ANKRD2 ASB6 ATXN1 BLZF1 CDCA4 CHORDC1 CRK ENO1 ENO3 FAM153B FAS FYN GSK3B HSPB2 HSPB3 HSPG2 IKZF3 KLHL41 KRTAP19-7 LAMTOR5 LHX4 MDM2 MSTN MYOZ1 MYOZ3 NUP133 PAX7 PDPK1 RELA SAPCD1 SIVA1 TRIM54 TRIM55 TRIM63 TTC19 TTN	5 interacting genes: ATXN1 PRKAR1A ROPN1 TCAP VEZF1
Entrez ID		8557	202134
HPRD ID		05133	18971
Ensembl ID		ENSG00000173991
Uniprot IDs		A2TDC0 O15273
PDB IDs		1YA5 2F8V
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process M Band Telethonin Binding Actinin Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glycolytic Process Through Glucose-6-phosphate Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Glycolytic Process Through Fructose-6-phosphate Regulation Of Myoblast Proliferation Z Disc Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization Skeletal Muscle Atrophy Myofibril Assembly FATZ Binding Response To Hydrogen Peroxide Activation-induced Cell Death Of T Cells Diapedesis Cellular Response To Hormone Stimulus Skeletal Muscle Adaptation Striated Muscle Atrophy Extrinsic Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway Glycolytic Process Muscle Atrophy Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ADP Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Enzyme Binding Purine Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Intracellular Signal Transduction Muscle System Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Phospholipase Activator Activity Nucleoside Diphosphate Catabolic Process Muscle Structure Development Reelin-mediated Signaling Pathway Skeletal Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Hormone Response To Reactive Oxygen Species Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Pyruvate Metabolic Process	Sarcomere Organization Anatomical Structure Formation Involved In Morphogenesis Actomyosin Structure Organization POZ Domain Binding Titin-telethonin Complex Titin Z Domain Binding Myosin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis CAMP-dependent Protein Kinase Complex Heart Development CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Nucleotide-activated Protein Kinase Complex Cellular Response To Glucagon Stimulus Actin Cytoskeleton Organization Negative Regulation Of Activated T Cell Proliferation Developmental Process Poly(G) Binding Nuclear Inclusion Body Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Differentiation Detection Of Muscle Stretch Otic Vesicle Formation Cardiac Muscle Hypertrophy In Response To Stress Adult Heart Development Titin Binding Cardiac Myofibril Assembly FATZ Binding Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Sperm Head-tail Coupling Apparatus Animal Organ Development Actin-myosin Filament Sliding
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