RBL2 and BRF1

Number of citations of the paper that reports this interaction (PubMedID 10330166)
45

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RBL2	BRF1
Description		RB transcriptional corepressor like 2	BRF1 general transcription factor IIIB subunit
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome	Transcription Factor TFIIIB Complex Nucleus Nucleoplasm Transcription Preinitiation Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Promoter-specific Chromatin Binding	RNA Polymerase III General Transcription Initiation Factor Activity RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Protein Binding Zinc Ion Binding TBP-class Protein Binding Metal Ion Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	DNA-templated Transcription Initiation Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter RRNA Transcription TRNA Transcription Transcription Preinitiation Complex Assembly
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat mass ( 28552196) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Huntington's disease progression ( 28642124) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 22139419 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252 29403010 32888494) Platelet distribution width ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		46 interacting genes: BRCA1 BRF1 BRF2 BTG3 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB1 PPP1R9B PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1	16 interacting genes: APP CSNK2A1 DTNBP1 GTF3C3 GTF3C4 GTF3C5 PCBD2 POLR3F RB1 RBL1 RBL2 RHOU RLIM TBP TP53 UBC
Entrez ID		5934	2972
HPRD ID		01576	05361
Ensembl ID		ENSG00000103479	ENSG00000185024
Uniprot IDs		Q08999	Q92994 V9HVY2
PDB IDs		4XI9 5C1D
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Nucleus Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cyclin A2-CDK2 Complex Cell Division Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition Response To Stress Transcription Regulator Complex DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Transcription Preinitiation Complex Assembly	Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity Regulation Of Lipid Kinase Activity RRNA Transcription Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III DNA-templated Transcription TRNA Transcription By RNA Polymerase III TRNA Transcription Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Chromatin Organization Nucleobase-containing Compound Biosynthetic Process Glial Cell Apoptotic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Transcription Initiation At RNA Polymerase III Promoter Regulation Of Cell Cycle G1/S Phase Transition DNA Binding Negative Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Promoter-specific Chromatin Binding DNA-templated Transcription Initiation Nucleus Transcription Regulator Complex RRNA Metabolic Process Regulation Of Mitotic Cell Cycle Epigenetic Regulation Of Gene Expression Regulation Of DNA-templated Transcription Negative Regulation Of Glial Cell Proliferation Regulation Of RNA Biosynthetic Process Core Promoter Sequence-specific DNA Binding Regulation Of Phosphorus Metabolic Process PML Body Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Molecular Function Activator Activity Chromatin Remodeling Regulation Of Cell Cycle Disordered Domain Specific Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Receptor Internalization
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