RBL2 and CREG1

Number of citations of the paper that reports this interaction (PubMedID 9710587)
75

Data Source:
HPRD (in vitro)

		RBL2	CREG1
Description		RB transcriptional corepressor like 2	cellular repressor of E1A stimulated genes 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Transcription Regulator Complex Cytoplasm Lysosome Endosome Endomembrane System Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Promoter-specific Chromatin Binding	Transcription Corepressor Activity
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endocytosis Autophagy Lysosome Organization Lysosomal Lumen Acidification Negative Regulation Of DNA-templated Transcription
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes	Neutrophil degranulation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat mass ( 28552196) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 31959851) Blood protein levels ( 30072576)
Interacting Genes		46 interacting genes: BRCA1 BRF1 BRF2 BTG3 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB1 PPP1R9B PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1	6 interacting genes: CAPN1 IGF2R RB1 RBL1 RBL2 TBP
Entrez ID		5934	8804
HPRD ID		01576	09897
Ensembl ID		ENSG00000103479	ENSG00000143162
Uniprot IDs		Q08999	O75629
PDB IDs		4XI9 5C1D	1XHN
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Nucleus Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cyclin A2-CDK2 Complex Cell Division Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition Response To Stress Transcription Regulator Complex DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Transcription Preinitiation Complex Assembly	Regulation Of Lipid Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Extracellular Exosome Regulation Of Catalytic Activity Phosphoprotein Binding Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Transcription Regulator Complex Regulation Of Kinase Activity Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Promoter-specific Chromatin Binding Enzyme Binding Protein Transport Into Plasma Membrane Raft Regulation Of Phosphorylation Protein Transport Into Membrane Raft Calpain Complex Male Gamete Generation Spermatogenesis Insulin-like Growth Factor Receptor Activity Response To Tetrachloromethane Flavin-dependent Sulfhydryl Oxidase Activity Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Chromatin Lock Complex Positive Regulation Of Collagen Fibril Organization TFIIB-class Transcription Factor Binding Gamete Generation Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Mammary Gland Involution Regulation Of Phosphorus Metabolic Process Glial Cell Apoptotic Process Rb-E2F Complex RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Regulation Of Potassium Ion Import NMDA Selective Glutamate Receptor Signaling Pathway Clathrin Coat Thiol Oxidase Activity Negative Regulation Of Myofibroblast Differentiation
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