RBL2 and BRF2

Number of citations of the paper that reports this interaction (PubMedID 10330166)
45

Data Source:
HPRD (in vivo)

		RBL2	BRF2
Description		RB transcriptional corepressor like 2	BRF2 general transcription factor IIIB subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome	Transcription Factor TFIIIB Complex Nucleus Nucleoplasm Transcription Preinitiation Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Promoter-specific Chromatin Binding	RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Metal Ion Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase III Transcription By RNA Polymerase II Cellular Response To Oxidative Stress Transcription Preinitiation Complex Assembly
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat mass ( 28552196) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Axial length ( 24144296)
Interacting Genes		46 interacting genes: BRCA1 BRF1 BRF2 BTG3 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB1 PPP1R9B PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1	3 interacting genes: RBL2 SNAPC4 TBP
Entrez ID		5934	55290
HPRD ID		01576	06115
Ensembl ID		ENSG00000103479	ENSG00000104221
Uniprot IDs		Q08999	Q9HAW0
PDB IDs		4XI9 5C1D	4ROC 4ROD 4ROE 5N9G 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Nucleus Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cyclin A2-CDK2 Complex Cell Division Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition Response To Stress Transcription Regulator Complex DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Transcription Preinitiation Complex Assembly	RNA Polymerase III General Transcription Initiation Factor Activity Transcription By RNA Polymerase III RNA Polymerase II General Transcription Initiation Factor Activity DNA Binding Regulation Of Lipid Kinase Activity SnRNA Transcription By RNA Polymerase II DNA-templated Transcription SnRNA-activating Protein Complex SnRNA Transcription By RNA Polymerase III RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Transcription By RNA Polymerase II RNA Polymerase Transcription Factor SL1 Complex TFIIB-class Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Binding Male Pronucleus Transcription Factor TFIIA Complex Aryl Hydrocarbon Receptor Binding Pronucleus RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Female Pronucleus Female Germ Cell Nucleus SnRNA Transcription Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor TFIID Complex Nucleobase-containing Compound Biosynthetic Process MRNA Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter SnRNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Preinitiation Complex Assembly Male Germ Cell Nucleus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Chromatin MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Euchromatin Nucleoplasm Promoter-specific Chromatin Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation
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