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RBL2 and RBBP8
Number of citations of the paper that reports this interaction (PubMedID
27107012
)
72
Data Source:
BioGRID
(two hybrid, two hybrid)
HPRD
(in vivo, two hybrid)
RBL2
RBBP8
Description
RB transcriptional corepressor like 2
RB binding protein 8, endonuclease
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Nucleolus
Cytosol
Extracellular Exosome
Nucleus
Nucleoplasm
Chromosome
Transcription Repressor Complex
Site Of Double-strand Break
BRCA1-C Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Protein Binding
Promoter-specific Chromatin Binding
Single-stranded DNA Endodeoxyribonuclease Activity
DNA Binding
Damaged DNA Binding
Transcription Corepressor Activity
Nuclease Activity
Endonuclease Activity
Protein Binding
Hydrolase Activity
Identical Protein Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Gene Expression
Cell Differentiation
Regulation Of Lipid Kinase Activity
Regulation Of Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Homologous Recombination
Blastocyst Hatching
DNA Repair
DNA Damage Response
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Homologous Recombination
Mitotic G2/M Transition Checkpoint
Negative Regulation Of DNA-templated Transcription
Cell Division
Meiotic Cell Cycle
DNA Strand Resection Involved In Replication Fork Processing
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
FOXO-mediated transcription of cell cycle genes
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Transcriptional Regulation by E2F6
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
Seckel syndrome
GWAS
Appendicular lean mass (
33097823
)
Body fat mass (
28552196
)
Fasting insulin (
34059833
)
General cognitive ability (
29844566
)
Height (
28552196
)
Hip circumference adjusted for BMI (
34021172
)
Intelligence (MTAG) (
29326435
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Metabolite levels (
23823483
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Eosinophil percentage of white cells (
27863252
)
Estradiol levels (
34255042
)
Height (
18391951
25429064
)
Hip circumference adjusted for BMI (
34021172
)
Intracranial aneurysm (
20364137
)
Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) (
27418160
)
Late-onset myasthenia gravis (
26562150
)
Lung function (FEV1) (
30061609
)
Lymphocyte count (
32888494
)
Scalp hair shape (
26926045
)
Tuberculosis (
20694014
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
46 interacting genes:
BRCA1
BRF1
BRF2
BTG3
CCNA1
CCNA2
CCND1
CCND3
CCNE1
CDK2
CDK4
CDK6
CREG1
DCTN1
DGKZ
E2F4
E2F5
EZH2
GRAMD4
HBP1
HDAC1
ID2
KMT5C
LBX1
LDHC
LIN52
MCM7
MNDA
PCBD1
PHB1
PPP1R9B
PPP2CA
RAF1
RBBP8
RBBP9
RINT1
SKP2
SMARCA4
SNW1
SUV39H1
TAF1
TOP1
TP53BP1
UBTF
USP4
XBP1
40 interacting genes:
ATM
BARD1
BRCA1
CLU
CTBP1
CUL3
DNA2
FXR2
FZR1
HID1
IGFBP7
IKBKG
IKZF1
IKZF3
KLHL15
LIMS1
LMO1
LMO2
LMO4
MAP2K4
NTAQ1
PAN2
PCNA
PELI2
PIAS4
PIN1
PRRG4
RAF1
RB1
RBL1
RBL2
RGS17
RNF4
SIAH1
SIAH2
TGIF2
TMEM54
TOPBP1
UBE2I
USP4
Entrez ID
5934
5932
HPRD ID
01576
04990
Ensembl ID
ENSG00000103479
ENSG00000101773
Uniprot IDs
Q08999
Q99708
PDB IDs
4XI9
5C1D
1Y98
2L4Z
4D2H
7BGF
Enriched GO Terms of Interacting Partners
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Cell Cycle G1/S Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Nucleoplasm
Regulation Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Nucleus
Cell Cycle Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Cyclin-dependent Protein Kinase Holoenzyme Complex
Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Regulation Of Primary Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Cellular Response To Stress
Negative Regulation Of Cell Cycle
Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Regulation Of Cell Population Proliferation
Transcription Corepressor Activity
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Damage Response
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cyclin A2-CDK2 Complex
Cell Division
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Cycle Phase Transition
Response To Stress
Transcription Regulator Complex
DNA Damage Checkpoint Signaling
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Nucleic Acid Metabolic Process
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Cycle Process
Transcription Preinitiation Complex Assembly
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Nucleus
Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Metabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cell Cycle Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Positive Regulation Of Metabolic Process
Protein Modification Process
BRCA1-B Complex
Regulation Of Lipid Kinase Activity
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Biosynthetic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Identical Protein Binding
Protein Ubiquitination
Mitotic G2 DNA Damage Checkpoint Signaling
Ubiquitin Protein Ligase Activity
Positive Regulation Of Protein Metabolic Process
Homologous Recombination
Nucleoplasm
Regulation Of Apoptotic Signaling Pathway
Protein Polyubiquitination
DNA Strand Resection Involved In Replication Fork Processing
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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