PACSIN1 and EHBP1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		PACSIN1	EHBP1
Description		protein kinase C and casein kinase substrate in neurons 1	EH domain binding protein 1
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ruffle Membrane Cell Projection Neuron Projection Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone	Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Endocytosis Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Development Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development	Endocytosis Protein Transport
Pathways		Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28448500 29273807) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Electrocardiographic traits (multivariate) ( 32602732) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196)	Apolipoprotein B levels ( 32203549) Body mass index ( 25673413 28892062) Coffee consumption ( 31046077) Coronary artery disease ( 33020668 29212778) Crohn's disease ( 22412388) Fruit consumption ( 32066663) Haemorrhoidal disease ( 33888516) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 28334899 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731 33339817) Myocardial infarction ( 33532862) Prostate cancer ( 18264098 25939597 19767753) Regular attendance at a religious group ( 29970889) Total cholesterol levels ( 29403010 33339817)
Interacting Genes		26 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SNCA SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL	3 interacting genes: EHD1 EHD2 PACSIN1
Entrez ID		29993	23301
HPRD ID		05936	10109
Ensembl ID		ENSG00000124507	ENSG00000115504
Uniprot IDs		Q5TZC3 Q9BY11	A0A140VK17 A8K930 Q8NDI1
PDB IDs		3HAH 3HAI 3Q84 3QNI	2D89 6ZSH 6ZSI 6ZSJ
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Vesicle-mediated Transport Actin Binding Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization SH3 Domain Binding Positive Regulation Of Organelle Organization Establishment Of Vesicle Localization Synaptic Vesicle Transport Identical Protein Binding Vesicle Localization Beta-tubulin Binding Phospholipid Binding Membrane Organization Regulation Of Organelle Organization Establishment Of Organelle Localization Histone H4K16 Acetyltransferase Activity Cytoskeleton Organization Histone H3K14 Acetyltransferase Activity Early Endosome Regulation Of Cytoskeleton Organization Histone H4K8 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Receptor-mediated Endocytosis Organelle Organization Histone H4K12 Acetyltransferase Activity Plasma Membrane Axolemma Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Cytoplasmic Vesicle Cytoplasm Protein Polymerization Plasma Membrane Tubulation Dynactin Binding Regulation Of Supramolecular Fiber Organization Synaptic Vesicle Priming Regulation Of DNA Biosynthetic Process Actin Filament-based Process Cell Projection Cytosol Inclusion Body Cellular Component Assembly Clathrin Coat Assembly Microtubule Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Ferrous Iron Binding Extracellular Exosome Microtubule Binding	Positive Regulation Of Endocytic Recycling Protein Localization To Plasma Membrane Regulation Of Myoblast Fusion Regulation Of Endocytic Recycling Protein Localization To Cell Periphery Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Myoblast Fusion Plasma Membrane Tubulation Cilium Assembly Cell Projection Organization Cilium Organization Protein Localization To Membrane Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Cellular Localization Establishment Of Localization In Cell Endocytosis Endocytic Vesicle Localization Within Membrane Endocytic Recycling Regulation Of Vesicle-mediated Transport Import Into Cell Regulation Of Plasma Membrane Bounded Cell Projection Organization Recycling Endosome Membrane Regulation Of Cell Projection Organization Presynaptic Endocytic Zone Axonemal Basal Plate Perinuclear Region Of Cytoplasm Organelle Assembly Plasma Membrane Organization Endosome Vesicle-mediated Transport To The Plasma Membrane Positive Regulation Of Intracellular Transport Regulation Of Developmental Process Regulation Of Cellular Component Organization Organelle Organization Positive Regulation Of Neuron Projection Development Regulation Of Embryonic Cell Shape Plasma Membrane Bounded Cell Projection Organization Ciliary Pocket Membrane Cytoskeleton Organization Protein-macromolecule Adaptor Activity Positive Regulation Of Cellular Component Organization Vesicle-mediated Transport Septin Cytoskeleton Organization Tongue Morphogenesis Intracellular Transport Endosomal Transport Regulation Of Intracellular Transport Cell Projection
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