PACSIN1 and MT-ATP8

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		PACSIN1	MT-ATP8
Description		protein kinase C and casein kinase substrate in neurons 1	ATP synthase F0 subunit 8
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ruffle Membrane Cell Projection Neuron Projection Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Proton-transporting ATP Synthase Complex
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Identical Protein Binding	Protein Binding Proton Transmembrane Transporter Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	Endocytosis Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Development Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development	ATP Biosynthetic Process Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		Clathrin-mediated endocytosis	Formation of ATP by chemiosmotic coupling Mitochondrial translation termination Cristae formation
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28448500 29273807) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Electrocardiographic traits (multivariate) ( 32602732) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		26 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SNCA SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL	4 interacting genes: GRB2 PACSIN1 RAPGEF2 WNK1
Entrez ID		29993	4509
HPRD ID		05936
Ensembl ID		ENSG00000124507	ENSG00000228253
Uniprot IDs		Q5TZC3 Q9BY11	P03928 U5YV54
PDB IDs		3HAH 3HAI 3Q84 3QNI	8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Vesicle-mediated Transport Actin Binding Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization SH3 Domain Binding Positive Regulation Of Organelle Organization Establishment Of Vesicle Localization Synaptic Vesicle Transport Identical Protein Binding Vesicle Localization Beta-tubulin Binding Phospholipid Binding Membrane Organization Regulation Of Organelle Organization Establishment Of Organelle Localization Histone H4K16 Acetyltransferase Activity Cytoskeleton Organization Histone H3K14 Acetyltransferase Activity Early Endosome Regulation Of Cytoskeleton Organization Histone H4K8 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Receptor-mediated Endocytosis Organelle Organization Histone H4K12 Acetyltransferase Activity Plasma Membrane Axolemma Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Cytoplasmic Vesicle Cytoplasm Protein Polymerization Plasma Membrane Tubulation Dynactin Binding Regulation Of Supramolecular Fiber Organization Synaptic Vesicle Priming Regulation Of DNA Biosynthetic Process Actin Filament-based Process Cell Projection Cytosol Inclusion Body Cellular Component Assembly Clathrin Coat Assembly Microtubule Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Ferrous Iron Binding Extracellular Exosome Microtubule Binding	Cell Development Neuron Development Positive Regulation Of Cellular Component Organization Ras Protein Signal Transduction Localization Within Membrane Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Dendrite Development Presynaptic Endocytic Zone Regulation Of Cellular Component Organization Cell-cell Junction Antigen Receptor-mediated Signaling Pathway Endosome Cellular Developmental Process Grb2-EGFR Complex Protein Localization To Plasma Membrane Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development CAMP-mediated Signaling Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Melanin Biosynthetic Process Beta-1 Adrenergic Receptor Binding Positive Regulation Of Dendritic Cell Apoptotic Process Lymphocyte Migration Into Lymph Node Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Chemokine (C-C Motif) Ligand 21 Signaling Pathway Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Protein Localization To Cell Periphery Regulation Of Cellular Component Size Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Signaling Pathway Small GTPase-mediated Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Insulin Receptor Substrate Binding Immune Response-activating Signaling Pathway Activation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Neurotrophin TRKA Receptor Binding Cellular Response To CGMP Negative Regulation Of Dendrite Morphogenesis Microvillus Organization Positive Regulation Of Neuron Migration Establishment Of Endothelial Intestinal Barrier Diacylglycerol Binding Regulation Of Melanin Biosynthetic Process Rap Protein Signal Transduction Positive Regulation Of Protein Binding Cellular Localization
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