PACSIN1 and SPTBN1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		PACSIN1	SPTBN1
Gene Name		protein kinase C and casein kinase substrate in neurons 1	spectrin, beta, non-erythrocytic 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Cell Junction COPI-coated Vesicle Cytoplasmic Vesicle Membrane Membrane-bounded Vesicle Ruffle Membrane Neuron Projection Axon Terminus Synapse Perinuclear Region Of Cytoplasm	Nucleolus Cytoplasm Cytosol Spectrin Spectrin-associated Cytoskeleton Axolemma M Band Cuticular Plate Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein Complex Binding Poly(A) RNA Binding
	Biological Process	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Establishment Of Protein Localization To Plasma Membrane Membrane Tubulation Positive Regulation Of Dendrite Development	Mitotic Cytokinesis Plasma Membrane Organization Common-partner SMAD Protein Phosphorylation SMAD Protein Import Into Nucleus Axon Guidance Golgi To Plasma Membrane Protein Transport Actin Filament Capping Membrane Assembly Protein Targeting To Plasma Membrane
Pathways			Interaction between L1 and Ankyrins Axon guidance Nephrin interactions L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Bone mineral density ( 22504420) Bone mineral density (spine) ( 19079262 19801982 18445777) Myopia (pathological) ( 22685421)
Protein-Protein Interactions		24 interactors: ANKRD24 ARHGAP17 ATP8 COBL COBLL1 DNM1 EHBP1 FTH1 GAS7 HTT JADE2 KAT7 KHDRBS1 PACSIN2 PACSIN3 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL	39 interactors: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 CPNE1 CPNE4 CSNK2A1 CTNNA1 DISC1 EPB41 EPB41L3 GRB2 GRIA2 MAPK14 MEF2C NF2 PACSIN1 PDE4D PJA1 PLCB1 PLEKHA5 PRKACA PYGO1 RINT1 SH3BP5 SMAD3 SMAD4 SMAD9 SNCA SPTAN1 SREBF2 STAT1 TNIK TRAF3IP1 YWHAG ZNF512B
Entrez ID		29993	6711
HPRD ID		05936	01683
Ensembl ID		ENSG00000124507	ENSG00000115306
Uniprot IDs		Q5TZC3 Q9BY11	B2ZZ89 Q01082
PDB IDs		3HAH 3HAI 3Q84 3QNI	1AA2 1BKR 3EDV
Enriched GO Terms of Interacting Partners?		Cell Projection Morphogenesis Cell Part Morphogenesis Actin Filament-based Process Endocytosis Cellular Component Assembly Vesicle-mediated Transport Cell Morphogenesis Regulation Of Cellular Component Organization Organelle Organization Cytoskeleton Organization Cell Projection Organization Actin Cytoskeleton Organization Neuron Development Neuron Projection Morphogenesis Regulation Of Endocytosis Actin Filament-based Movement Endomembrane System Organization Generation Of Neurons Neuron Differentiation Histone H4-K12 Acetylation Membrane Tubulation Neurogenesis Neuron Projection Development Actin Polymerization Or Depolymerization Histone H4-K5 Acetylation Histone H4-K8 Acetylation Membrane Organization Axonogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Protein Polymerization Anatomical Structure Morphogenesis Axon Development Regulation Of Cellular Process Regulation Of Protein Depolymerization Positive Regulation Of Protein Depolymerization Actin Filament Organization Cell Morphogenesis Involved In Neuron Differentiation Membrane Assembly Regulation Of Cell Projection Assembly Regulation Of Protein Complex Disassembly Protein Complex Assembly Movement Of Cell Or Subcellular Component Cellular Protein Complex Assembly Membrane Biogenesis Cell Differentiation Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Complex Disassembly Cell Morphogenesis Involved In Differentiation Axon Guidance	Regulation Of Cellular Component Organization System Development Intracellular Signal Transduction Nervous System Development Regulation Of Cellular Localization Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Regulation Of Phosphorylation Regulation Of Signal Transduction Multicellular Organismal Development Anatomical Structure Development Cell-cell Junction Organization Regulation Of Intracellular Transport Developmental Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Neurogenesis Negative Regulation Of Phosphorylation Apoptotic Process Signaling Anatomical Structure Morphogenesis Negative Regulation Of Cellular Metabolic Process Cell Development Organelle Organization Programmed Cell Death Cell Communication Generation Of Neurons Kidney Development Cell Death Cell Morphogenesis Death Regulation Of Protein Metabolic Process Cell-cell Junction Assembly Epithelium Development Cellular Response To Organonitrogen Compound Renal System Development Cell Activation Organ Development Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Protein Metabolic Process Cell Projection Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Neuron Development
Tagcloud ?		10a autophagic autophagosome autophagosomes bub1 catabolic cdkl3 csnk1a1 dapk2 endolysosomal flux functioned immortalized kinome macroautophagy maintains manipulation mcf mtorc1 nek4 pklr possibilities protects scyl1 shed sirnas starvation stresses wnk2	adipocyte analyzing classified cytoskeletal differentially exposed exposure fact fatty insights k18 keratin mediating morphogenesis nicotine obstructive osf3 peroxiredoxin phosphoprotein phosphoproteins phosphoproteomic regeneration semi sixteen smoke sought spectrin spt16 tobacco
Tagcloud (Difference) ?		10a autophagic autophagosome autophagosomes bub1 catabolic cdkl3 csnk1a1 dapk2 endolysosomal flux functioned immortalized kinome macroautophagy maintains manipulation mcf mtorc1 nek4 pklr possibilities protects scyl1 shed sirnas starvation stresses wnk2	adipocyte analyzing classified cytoskeletal differentially exposed exposure fact fatty insights k18 keratin mediating morphogenesis nicotine obstructive osf3 peroxiredoxin phosphoprotein phosphoproteins phosphoproteomic regeneration semi sixteen smoke sought spectrin spt16 tobacco
Tagcloud (Intersection) ?