PACSIN1 and TPM4

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		PACSIN1	TPM4
Description		protein kinase C and casein kinase substrate in neurons 1	tropomyosin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ruffle Membrane Cell Projection Neuron Projection Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone	Stress Fiber Podosome Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Focal Adhesion Membrane Cortical Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Identical Protein Binding	Actin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Endocytosis Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Development Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development	Osteoblast Differentiation Muscle Contraction Actin Filament Organization Platelet Formation
Pathways		Clathrin-mediated endocytosis	Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28448500 29273807) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Electrocardiographic traits (multivariate) ( 32602732) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196)	Longevity ( 33657282) Mean platelet volume ( 22139419 22423221 27863252 31080455 32888494) Platelet count ( 22139419 22423221 26805783 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		26 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SNCA SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL	12 interacting genes: DANCR ISG15 JRK LNX1 NOD2 PACSIN1 PDE4B PICK1 SNAPIN TCERG1 TRIP6 USP7
Entrez ID		29993	7171
HPRD ID		05936	11734
Ensembl ID		ENSG00000124507	ENSG00000167460
Uniprot IDs		Q5TZC3 Q9BY11	A0A2R8Y5V9 K7ENT6 P67936 V9HW56
PDB IDs		3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Vesicle-mediated Transport Actin Binding Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization SH3 Domain Binding Positive Regulation Of Organelle Organization Establishment Of Vesicle Localization Synaptic Vesicle Transport Identical Protein Binding Vesicle Localization Beta-tubulin Binding Phospholipid Binding Membrane Organization Regulation Of Organelle Organization Establishment Of Organelle Localization Histone H4K16 Acetyltransferase Activity Cytoskeleton Organization Histone H3K14 Acetyltransferase Activity Early Endosome Regulation Of Cytoskeleton Organization Histone H4K8 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Receptor-mediated Endocytosis Organelle Organization Histone H4K12 Acetyltransferase Activity Plasma Membrane Axolemma Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Cytoplasmic Vesicle Cytoplasm Protein Polymerization Plasma Membrane Tubulation Dynactin Binding Regulation Of Supramolecular Fiber Organization Synaptic Vesicle Priming Regulation Of DNA Biosynthetic Process Actin Filament-based Process Cell Projection Cytosol Inclusion Body Cellular Component Assembly Clathrin Coat Assembly Microtubule Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Ferrous Iron Binding Extracellular Exosome Microtubule Binding	Synaptic Vesicle Regulation Of Cell Communication Vesicle-mediated Transport In Synapse Regulation Of Signaling Cellular Response To Epinephrine Stimulus Regulation Of Vesicle-mediated Transport Response To Epinephrine Regulation Of Transport Regulation Of Autophagy Regulation Of Establishment Of Protein Localization Cytoplasm Ciliary Base Intracellular Protein Transport Modulation Of Chemical Synaptic Transmission Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Nutrient Levels Developmental Maturation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Late Endosome To Lysosome Transport Presynaptic Endocytic Zone Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Regulation Of Gluconeogenesis Regulation Of Interleukin-2 Production Protein Modification Process Cellular Response To Nutrient Levels Regulation Of Intracellular Transport TORC1 Signaling Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Protein Ubiquitination Regulation Of Interleukin-10 Production Negative Regulation Of TORC1 Signaling Protein-containing Complex Localization Membrane Organization Golgi Vesicle Fusion To Target Membrane Positive Regulation Of Type II Interferon Production Negative Regulation Of Relaxation Of Cardiac Muscle Detection Of Peptidoglycan Intracellular Protein Localization Protein Localization To Membrane Regulation Of Cardiac Muscle Contraction Regulation Of Endocytosis Protein Modification By Small Protein Conjugation Perinuclear Region Of Cytoplasm Phagocytic Vesicle TOR Signaling Neuron Projection Cytosol Negative Regulation Of TOR Signaling
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