PACSIN1

Name	protein kinase C and casein kinase substrate in neurons 1
Structure
Interactors	26 interactors: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SNCA SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ruffle Membrane Cell Projection Neuron Projection Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Endocytosis Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Development Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development
Pathways	Clathrin-mediated endocytosis
GWAS	Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index ( 28448500 29273807 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index in physically active individuals ( 28448500 ) Electrocardiographic traits (multivariate) ( 32602732 ) Free thyroxine concentration ( 30367059 ) High density lipoprotein cholesterol levels ( 30498476 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 27569725 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 28552196 )
Entrez ID	29993
HPRD ID	05936
Ensembl ID	ENSG00000124507
Uniprot IDs	Q5TZC3 Q9BY11
PDB IDs	3HAH 3HAI 3Q84 3QNI
GO Terms Enriched among Interactors ?	Endocytosis Import Into Cell Vesicle-mediated Transport Actin Binding Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization SH3 Domain Binding Positive Regulation Of Organelle Organization Establishment Of Vesicle Localization Synaptic Vesicle Transport Identical Protein Binding Vesicle Localization Beta-tubulin Binding Phospholipid Binding Membrane Organization Regulation Of Organelle Organization Establishment Of Organelle Localization Histone H4K16 Acetyltransferase Activity Cytoskeleton Organization Histone H3K14 Acetyltransferase Activity Early Endosome Regulation Of Cytoskeleton Organization Histone H4K8 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Receptor-mediated Endocytosis Organelle Organization Histone H4K12 Acetyltransferase Activity Plasma Membrane Axolemma Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Cytoplasmic Vesicle Cytoplasm Protein Polymerization Plasma Membrane Tubulation Dynactin Binding Regulation Of Supramolecular Fiber Organization Synaptic Vesicle Priming Regulation Of DNA Biosynthetic Process Actin Filament-based Process Cell Projection Cytosol Inclusion Body Cellular Component Assembly Clathrin Coat Assembly Microtubule Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Ferrous Iron Binding Extracellular Exosome Microtubule Binding