PACSIN1 and PACSIN2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		PACSIN1	PACSIN2
Description		protein kinase C and casein kinase substrate in neurons 1	protein kinase C and casein kinase substrate in neurons 2
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Membrane COPI-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ruffle Membrane Cell Projection Neuron Projection Axon Terminus Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynaptic Endocytic Zone	Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion Cilium Membrane Nuclear Speck Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ruffle Membrane Centriolar Satellite Cell Projection Recycling Endosome Membrane Extracellular Exosome Anchoring Junction Glutamatergic Synapse
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Identical Protein Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Cadherin Binding Phosphatidic Acid Binding
	Biological Process	Endocytosis Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Development Neuron Projection Morphogenesis Protein Localization To Membrane Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Dendrite Development	Cell Migration Involved In Sprouting Angiogenesis Endocytosis Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Caveola Assembly Caveolin-mediated Endocytosis Plasma Membrane Tubulation
Pathways		Clathrin-mediated endocytosis	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28448500 29273807) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Electrocardiographic traits (multivariate) ( 32602732) Free thyroxine concentration ( 30367059) High density lipoprotein cholesterol levels ( 30498476) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 27569725) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196)	Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Prostate cancer (SNP x SNP interaction) ( 22219177)
Interacting Genes		26 interacting genes: ANKRD24 ARHGAP17 DNM1 EHBP1 FTH1 GAS7 HTT ITCH JADE2 KAT7 KHDRBS1 MAPT MT-ATP8 PACSIN2 PACSIN3 PLEKHF2 POT1 RTKN2 SNCA SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL	18 interacting genes: DNM1 EHD1 EXOSC8 FASLG GSC2 MECOM MEOX2 PACSIN1 PACSIN3 PBX4 POT1 RIC8A SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL
Entrez ID		29993	11252
HPRD ID		05936	05390
Ensembl ID		ENSG00000124507	ENSG00000100266
Uniprot IDs		Q5TZC3 Q9BY11	Q6FIA3 Q9UNF0
PDB IDs		3HAH 3HAI 3Q84 3QNI	3ABH 3ACO 3HAJ 3Q0K
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Vesicle-mediated Transport Actin Binding Regulation Of Cellular Component Organization Negative Regulation Of Cellular Component Organization SH3 Domain Binding Positive Regulation Of Organelle Organization Establishment Of Vesicle Localization Synaptic Vesicle Transport Identical Protein Binding Vesicle Localization Beta-tubulin Binding Phospholipid Binding Membrane Organization Regulation Of Organelle Organization Establishment Of Organelle Localization Histone H4K16 Acetyltransferase Activity Cytoskeleton Organization Histone H3K14 Acetyltransferase Activity Early Endosome Regulation Of Cytoskeleton Organization Histone H4K8 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Receptor-mediated Endocytosis Organelle Organization Histone H4K12 Acetyltransferase Activity Plasma Membrane Axolemma Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Cytoplasmic Vesicle Cytoplasm Protein Polymerization Plasma Membrane Tubulation Dynactin Binding Regulation Of Supramolecular Fiber Organization Synaptic Vesicle Priming Regulation Of DNA Biosynthetic Process Actin Filament-based Process Cell Projection Cytosol Inclusion Body Cellular Component Assembly Clathrin Coat Assembly Microtubule Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Ferrous Iron Binding Extracellular Exosome Microtubule Binding	Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Positive Regulation Of Cellular Component Organization Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Import Into Cell Membrane Organization Telomeric D-loop Disassembly Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Telomeric Loop Disassembly Endocytosis Negative Regulation Of Chromosome Organization Plasma Membrane Tubulation DNA Biosynthetic Process Regulation Of Plasma Membrane Organization Positive Regulation Of Organelle Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Organization Lipid Binding Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Organelle Organization Negative Regulation Of DNA Biosynthetic Process Vesicle Budding From Membrane Clathrin Coat Assembly Involved In Endocytosis Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Chromosome, Telomeric Region Presynaptic Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Endosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Presynaptic Endocytic Zone Osmosensor Activity Blood Vessel Endothelial Cell Delamination
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