S100A8 and TUBA4A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		S100A8	TUBA4A
Description		S100 calcium binding protein A8	tubulin alpha 4a
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Intermediate Filament Cytoskeleton Extracellular Exosome Calprotectin Complex S100A8 Complex	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Metal Ion Binding Calcium-dependent Protein Binding Arachidonate Binding RAGE Receptor Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Immune System Process Leukocyte Migration Involved In Inflammatory Response Chronic Inflammatory Response Peptide Secretion Positive Regulation Of Peptide Secretion Autophagy Apoptotic Process Chemotaxis Inflammatory Response Response To Zinc Ion Astrocyte Development Peptidyl-cysteine S-nitrosylation Positive Regulation Of Cell Growth Neutrophil Chemotaxis Response To Lipopolysaccharide Regulation Of Toll-like Receptor Signaling Pathway Autocrine Signaling Defense Response To Bacterium Endothelial Cell Migration Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate
Diseases
GWAS		Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897) Monocyte count ( 32888494)	Platelet distribution width ( 27863252 32888494) Severe autoimmune type 2 diabetes ( 34737425)
Interacting Genes		22 interacting genes: APP CDKN1A CEACAM3 CHGB ERG28 GDF9 IGSF21 KLC2 LRIF1 NCF2 PCNA PDCD11 PPIA PRMT1 PTEN RAB17 S100A9 TP53 TUBA1A TUBA4A TUBB UNC119	53 interacting genes: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 YWHAG ZAP70
Entrez ID		6279	7277
HPRD ID		00471	01851
Ensembl ID		ENSG00000143546	ENSG00000127824
Uniprot IDs		P05109	P68366
PDB IDs		1MR8 1XK4 4GGF 4XJK 5HLO 5HLV 5W1F 6DS2 7QUV 8SJB 8SJC
Enriched GO Terms of Interacting Partners?		Response To Light Stimulus Molecular Function Activator Activity PCNA-p21 Complex Enzyme Binding Response To Radiation Regulation Of Phosphorus Metabolic Process Regulation Of Growth RAGE Receptor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Microtubule-based Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Nuclear Envelope Lumen Heparan Sulfate Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Phosphate Metabolic Process Stress-induced Premature Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Forebrain Morphogenesis Cytoskeleton-dependent Intracellular Transport Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Growth Regulation Of DNA Biosynthetic Process Replicative Senescence Synapse Maturation Cellular Response To UV Mitotic G1/S Transition Checkpoint Signaling Response To L-glutamate Structural Constituent Of Cytoskeleton Synapse Organization Protein-containing Complex Protein Serine/threonine Kinase Binding Negative Regulation Of Protein Phosphorylation Heart Development Cellular Response To Light Stimulus Circadian Behavior Rhythmic Behavior Response To Amino Acid Regulation Of DNA Replication Negative Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Dentate Gyrus Development Regulation Of Cellular Component Organization Positive Regulation Of Phosphate Metabolic Process Regulation Of Synapse Organization Positive Regulation Of Excitatory Postsynaptic Potential Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process Cytosol Regulation Of Cellular Response To Stress Negative Regulation Of DNA Metabolic Process	Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly
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