S100A8 and RAB17

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		S100A8	RAB17
Description		S100 calcium binding protein A8	RAB17, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Intermediate Filament Cytoskeleton Extracellular Exosome Calprotectin Complex S100A8 Complex	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Dendrite Cytoplasmic Vesicle Dendrite Cytoplasm Melanosome Cell Projection Neuronal Cell Body Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Metal Ion Binding Calcium-dependent Protein Binding Arachidonate Binding RAGE Receptor Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Immune System Process Leukocyte Migration Involved In Inflammatory Response Chronic Inflammatory Response Peptide Secretion Positive Regulation Of Peptide Secretion Autophagy Apoptotic Process Chemotaxis Inflammatory Response Response To Zinc Ion Astrocyte Development Peptidyl-cysteine S-nitrosylation Positive Regulation Of Cell Growth Neutrophil Chemotaxis Response To Lipopolysaccharide Regulation Of Toll-like Receptor Signaling Pathway Autocrine Signaling Defense Response To Bacterium Endothelial Cell Migration Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Intracellular Protein Transport Protein Transport Establishment Of Melanosome Localization Melanosome Transport Endocytic Recycling Transcytosis Filopodium Assembly Regulation Of Dendrite Development Regulation Of Filopodium Assembly Regulation Of Synapse Assembly Cilium Assembly Anterograde Dendritic Transport Plasma Membrane Bounded Cell Projection Assembly
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	RAB geranylgeranylation
Drugs		Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897) Monocyte count ( 32888494)	Obesity-related traits ( 23251661)
Interacting Genes		22 interacting genes: APP CDKN1A CEACAM3 CHGB ERG28 GDF9 IGSF21 KLC2 LRIF1 NCF2 PCNA PDCD11 PPIA PRMT1 PTEN RAB17 S100A9 TP53 TUBA1A TUBA4A TUBB UNC119	11 interacting genes: ACVR1 BOLA3 CSTPP1 FAM9B MAGEA1 NUDT3 RAB7A RABAC1 S100A8 SMURF2 SNCA
Entrez ID		6279	64284
HPRD ID		00471	11468
Ensembl ID		ENSG00000143546	ENSG00000124839
Uniprot IDs		P05109	Q9H0T7
PDB IDs		1MR8 1XK4 4GGF 4XJK 5HLO 5HLV 5W1F 6DS2 7QUV 8SJB 8SJC
Enriched GO Terms of Interacting Partners?		Response To Light Stimulus Molecular Function Activator Activity PCNA-p21 Complex Enzyme Binding Response To Radiation Regulation Of Phosphorus Metabolic Process Regulation Of Growth RAGE Receptor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Microtubule-based Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Nuclear Envelope Lumen Heparan Sulfate Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Phosphate Metabolic Process Stress-induced Premature Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Forebrain Morphogenesis Cytoskeleton-dependent Intracellular Transport Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Growth Regulation Of DNA Biosynthetic Process Replicative Senescence Synapse Maturation Cellular Response To UV Mitotic G1/S Transition Checkpoint Signaling Response To L-glutamate Structural Constituent Of Cytoskeleton Synapse Organization Protein-containing Complex Protein Serine/threonine Kinase Binding Negative Regulation Of Protein Phosphorylation Heart Development Cellular Response To Light Stimulus Circadian Behavior Rhythmic Behavior Response To Amino Acid Regulation Of DNA Replication Negative Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Dentate Gyrus Development Regulation Of Cellular Component Organization Positive Regulation Of Phosphate Metabolic Process Regulation Of Synapse Organization Positive Regulation Of Excitatory Postsynaptic Potential Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process Cytosol Regulation Of Cellular Response To Stress Negative Regulation Of DNA Metabolic Process	Negative Regulation Of Signal Transduction Endocardial Cushion Cell Fate Commitment Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Cell Communication SMAD Binding Negative Regulation Of Signaling S100A8 Complex Positive Regulation Of Secretion Calprotectin Complex Neutrophil Aggregation Response To Desipramine Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Transporter Regulator Activity Negative Regulation Of Exocytosis Vesicle-mediated Transport In Synapse Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Lipophagy Synaptic Vesicle Recycling Via Endosome 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Response To Lipoic Acid Establishment Of Vesicle Localization BMP Receptor Complex Peptidyl-cysteine S-nitrosylation Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Exosomal Secretion
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