S100A8 and NCF2

Number of citations of the paper that reports this interaction (PMID 15642721)
28

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		S100A8	NCF2
Gene Name		S100 calcium binding protein A8	neutrophil cytosolic factor 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Extracellular Vesicular Exosome	Acrosomal Vesicle Nucleolus Cytoplasm Cytosol Phagolysosome NADPH Oxidase Complex
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding	Protein Binding Protein C-terminus Binding Electron Carrier Activity Rac GTPase Binding
	Biological Process	Cytokine Production Leukocyte Migration Involved In Inflammatory Response Acute Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Peptide Secretion Autophagy Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Zinc Ion Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Response To Lipopolysaccharide Chemokine Production Wound Healing Defense Response To Bacterium Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Cellular Defense Response Aging Response To Glucose Response To Activity Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Response To Laminar Fluid Shear Stress Response To Drug Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Respiratory Burst Positive Regulation Of Blood Pressure Vascular Endothelial Growth Factor Receptor Signaling Pathway Interaction With Host Response To Hyperoxia Phagosome Maturation
Pathways			Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: APP C14orf1 CDKN1A CEACAM3 CHGB GDF9 IGSF21 KLC2 LRIF1 NCF2 PDCD11 PPIA PRMT1 RAB17 S100A9 TP53 TUBA4A UNC119	14 interactors: ACTB CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1
Entrez ID		6279	4688
HPRD ID		00471	01991
Ensembl ID		ENSG00000143546	ENSG00000116701
Uniprot IDs		P05109	P19878
PDB IDs		1MR8 1XK4 4GGF	1E96 1HH8 1K4U 1OEY 1WM5 2DMO
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Platelet Degranulation Immune System Process Stress-induced Premature Senescence Regulation Of Body Fluid Levels Wound Healing Regulation Of Growth Mitotic Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Response To Wounding Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Immune Response Negative Regulation Of Cell Growth Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Cellular Senescence Response To Hyperoxia Platelet Activation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Positive Regulation Of Cell Cycle Process Regulation Of Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cell Cycle Phase Transition Response To Stimulus Response To Abiotic Stimulus Positive Regulation Of Programmed Cell Death Axon Cargo Transport Negative Regulation Of Growth Response To Stress Positive Regulation Of Cell Death Response To External Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Positive Regulation Of Neuron Apoptotic Process Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To UV Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Clathrin-mediated Endocytosis Uncoating Of Virus Mitotic Cell Cycle Process	Vascular Endothelial Growth Factor Receptor Signaling Pathway Innate Immune Response Immune Response Immune System Process Response To Stress Defense Response Single Organismal Cell-cell Adhesion Neutrophil Aggregation Regulation Of Body Fluid Levels Chemotaxis Wound Healing Homotypic Cell-cell Adhesion Hydrogen Peroxide Metabolic Process Organelle Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Sequestering Of Zinc Ion Cell Adhesion Response To External Stimulus Phagosome Maturation Blood Coagulation Inflammatory Response Hemostasis Homeostatic Process Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Antigen Processing And Presentation Of Peptide Antigen Movement Of Cell Or Subcellular Component Hydrogen Peroxide Biosynthetic Process Chemokine Production Regulation Of Hydrogen Peroxide Metabolic Process Sequestering Of Metal Ion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Leukocyte Aggregation Antigen Processing And Presentation Regulation Of Respiratory Burst Respiratory Burst Ephrin Receptor Signaling Pathway Chronic Inflammatory Response Positive Regulation Of Lamellipodium Assembly Interaction With Host Leukocyte Cell-cell Adhesion Leukocyte Chemotaxis Cellular Zinc Ion Homeostasis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Reactive Oxygen Species Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Cell Projection Assembly
Tagcloud ?		a9 auscan australian canadian erythrocyte esr exploratory grades hand hip inverse joint kellgren knee lawrence mcmaster narrowing oa ontario osteoarthritis osteophytes sedimentation space stiffness structural sum synovial universities womac	anion besides biopsies chl copy cyba cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide
Tagcloud (Difference) ?		a9 auscan australian canadian erythrocyte esr exploratory grades hand hip inverse joint kellgren knee lawrence mcmaster narrowing oa ontario osteoarthritis osteophytes sedimentation space stiffness structural sum synovial universities womac	anion besides biopsies chl copy cyba cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf4 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide
Tagcloud (Intersection) ?